• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-CD106 antibody :: Mouse CD106 Monoclonal Antibody

Scan QR to view Datasheet
Catalog # MBS219517
Unit / Price
  0.1 mg  /  $290 +1 FREE 8GB USB
Product Name

CD106, Monoclonal Antibody

Also Known As

MOUSE ANTI RAT CD106:FITC

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
739
3D Structure
ModBase 3D Structure for P29534
Clonality
Monoclonal
Isotype
IgG1
Clone Number
MR106
Host
Mouse
Form/Format
FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
Concentration
IgG concentration 0.1mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
Preparation
Immunogen
Rat CD106-transfected L5178Y cells
Buffer Solution
Target Species
Rat
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-CD106 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD106 antibody
Mouse anti Rat CD106 antibody, clone MR106 specifically recognizes rat CD106, otherwise known as VCAM-1 (vascular adhesion molecule 1), a 110kDa inducible type I transmembrane glycoprotein and member of the immunoglobulin supergene family, which is predominantly expressed on vascular endothelium, and also on bone marrow stromal cells, follicular dendritic cells and some macrophages. CD106 interacts with the lymphocyte homing receptor VLA-4 (alpha4 beta1 integrin) and LPAM-1 (alpha4 beta7 integrin) and mediates leucocyte-endothelial cell adhesion and signal transduction. Expression of CD106 is upregulated following cytokine activation, and endothelial CD106 plays a role in the extravasation of leucocytes from blood vessels during inflammation.
Applications Tested/Suitable for anti-CD106 antibody
Flow cytometry (FC/FACS)
Application Notes for anti-CD106 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/5

Testing Data of anti-CD106 antibody
Staining of rat bone marrow cells with Mouse anti Rat CD106:RPE (MBS219407)
anti-CD106 antibody Testing Data image
Testing Data of anti-CD106 antibody
Staining of rat bone marrow cells with Mouse anti Rat CD106:FITC
anti-CD106 antibody Testing Data image
Testing Data of anti-CD106 antibody
Staining of rat bone marrow cells with Mouse anti Rat CD106:Alexa Fluor 647 (MBS219615A647)
anti-CD106 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for CD106. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,246 Da
NCBI Official Full Name
vascular cell adhesion protein 1
NCBI Official Synonym Full Names
vascular cell adhesion molecule 1
NCBI Official Symbol
Vcam1  [Similar Products]
NCBI Official Synonym Symbols
VCAM1B
  [Similar Products]
NCBI Protein Information
vascular cell adhesion protein 1; V-CAM 1; VCAM-1
UniProt Protein Name
Vascular cell adhesion protein 1
UniProt Synonym Protein Names
CD_antigen: CD106
UniProt Gene Name
Vcam1  [Similar Products]
UniProt Synonym Gene Names
Vcam-1; V-CAM 1; VCAM-1  [Similar Products]
UniProt Entry Name
VCAM1_RAT
NCBI Summary for CD106
binds integrin very late antigen (VLA4); plays a role in cell adhesion [RGD, Feb 2006]
UniProt Comments for CD106
VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral

Cellular Component: Golgi apparatus; extracellular space; microvillus; cell surface; endoplasmic reticulum; apical part of cell; early endosome; integral to membrane; podosome; sarcolemma; filopodium; external side of plasma membrane

Molecular Function: amine oxidase activity; integrin binding; cell adhesion molecule binding

Biological Process: response to nicotine; chronic inflammatory response; viral reproduction; heart development; cell-matrix adhesion; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; response to ionizing radiation; amine metabolic process; cell adhesion; leukocyte tethering or rolling; response to nutrient; acute inflammatory response; aging
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000