P05555.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
115,196 Da
NCBI Official Full Name
Integrin alpha-M
NCBI Official Synonym Full Names
integrin alpha M
NCBI Official Synonym Symbols
CR3; CR3A; MAC1; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik [Similar Products]
NCBI Protein Information
integrin alpha-M; CD11 antigen-like family member B; CD11B (p170); CR-3 alpha chain; Mac-1 alpha; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component receptor 3 alpha-a; complement receptor type 3; leukocyte adhesion receptor MO1; macrophage antigen alpha
UniProt Protein Name
Integrin alpha-M
UniProt Synonym Protein Names
CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; CD_antigen: CD11b
UniProt Entry Name
ITAM_MOUSE
UniProt Comments for CD11b
ITGAM: a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral
Cellular Component: cell surface; membrane; integral to membrane; nucleus; integrin complex; external side of plasma membrane
Molecular Function: heparin binding; heparan sulfate proteoglycan binding; opsonin binding; protein heterodimerization activity; metal ion binding; glycoprotein binding
Biological Process: integrin-mediated signaling pathway; neutrophil chemotaxis; cell-cell adhesion; leukocyte adhesion; microglia development; cellular extravasation; activated T cell proliferation; cell adhesion; leukocyte migration during inflammatory response
Research Articles on CD11b
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Pathways associated with anti-CD11b antibody
Organs/Tissues associated with anti-CD11b antibody
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