• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-CD160 antibody :: Rat CD160 Monoclonal Antibody

Scan QR to view Datasheet
Catalog # MBS832170
Unit / Price
  0.05 mg  /  $250 +1 FREE 8GB USB
  0.1 mg  /  $395 +1 FREE 8GB USB
Flow Cytometry (FC/FACS)
Product Name

CD160, Monoclonal Antibody

Popular Item
Also Known As

CD160 antibody (PE)

Product Synonym Names
Monoclonal CD160; Anti-CD160; NK1; CD-160; CD 160; CD160; NK28; BY55
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
181
OMIM
604463
3D Structure
ModBase 3D Structure for O95971
Clonality
Monoclonal
Isotype
IgG2a kappa
Clone Number
CNX46-3
Host
Rat
Specificity
Human
Form/Format
Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.
Concentration
200 ug/ml (lot specific)
Biological Significance
CD160 is a glycosylphosphatidylinositol -anchored Ig-like glycoprotein first identified on human lymphocytes with the monoclonal antibody BY55. In mice, CD160 is expressed on almost all iIELs, NKT cells, most TCRgamma delta T cells, few NK cells and a minor subset of CD8+ T cells. Murine CD160 has been shown to bind to a wide range of classical and non classical MHC class I molecules and regulate NK cell activation. In vitro, CD3 activation of murine CD8+ T cells increases the expression of CD160 and induces the release of soluble CD160. In human, CD160 mAb cross-linking triggers TNF alpha, IFNgamma and IL-6 cytokine production by peripheral blood NK cells and inhibits tube formation and induces apoptosis of endothelial cells. In mice, cross-linking of CD160 with the CNX46-3 antibody regulates NK cell activation both positively and negatively, depending on the stimulus.
Tag/Conjugate
PE
Preparation and Storage
Store at 2-8 degree C. Do not freeze. Protect from light.
Other Notes
Small volumes of anti-CD160 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD160 antibody
Rat monoclonal CD160 antibody (PE)
Applications Tested/Suitable for anti-CD160 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD160 antibody
FC: <= 0.125 ug/test

A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest

Flow Cytometry (FC/FACS) of anti-CD160 antibody
Staining of C57BL/6 splenocytes with CD3 antibody (FITC), NK1.1 antibody (APC), and 0.5 ug of CD160 antibody (PE). The histogram (right) demonstrates staining of CD160 on NK1.1+CD3- cells (red histogram) and NK1.1+CD3+ cells (black histogram), as gated in the dot plot (left).
anti-CD160 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
NCBI/Uniprot data below describe general gene information for CD160. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
19,810 Da
NCBI Official Full Name
CD160 antigen
NCBI Official Synonym Full Names
CD160 molecule
NCBI Official Symbol
CD160  [Similar Products]
NCBI Official Synonym Symbols
NK1; BY55; NK28
  [Similar Products]
NCBI Protein Information
CD160 antigen
UniProt Protein Name
CD160 antigen
UniProt Synonym Protein Names
Natural killer cell receptor BY55; CD_antigen: CD160
Protein Family
UniProt Gene Name
CD160  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
BY55_HUMAN
NCBI Summary for CD160
CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]
UniProt Comments for CD160
Receptor showing broad specificity for both classical and non-classical MHC class I molecules.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000