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anti-CD321 antibody :: Rat CD321 Monoclonal Antibody

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Catalog # MBS212721
Unit / Price
  0.1 mg  /  $210 +1 FREE 8GB USB
Product Name

CD321, Monoclonal Antibody

Popular Item
Also Known As

RAT ANTI MOUSE CD321

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
300
3D Structure
ModBase 3D Structure for O88792
Clonality
Monoclonal
Isotype
IgG1
Clone Number
H202-106
Host
Rat
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium Azide
Preparation
Immunogen
MTE1/MTE2 stromal cell lines.
Fusion Partners
Target Species
Mouse
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-CD321 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD321 antibody
Rat anti Mouse CD321 antibody, clone H202-106 recognizes murine CD321, which is also known as junctional adhesion molecule 1 (JAM-1). CD321 is a 32-41kD glycoprotein, which shares similarities with related proteins JAM-2 and JAM-3. CD321 is a multifunctional protein that is primarily expressed by platelets, endothelial and epithelial cells. The CD321 protein co-localises with tight junction molecules in both epithelial and endothelial cells and plays an important role in the regulation of junctional integrity and permeability. In addition, CD321 is a ligand for the integrin LFA-1 and is also involved in the transmigration of leucocytes.
Applications Tested/Suitable for anti-CD321 antibody
Immunohistology Frozen, Flow cytometry (FC/FACS), Immunoprecipitation (IP)
Application Notes for anti-CD321 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/100; Maximum Dilution: 1/200

Testing Data of anti-CD321 antibody
Staining of mouse peripheral blood platelets with Rat anti Mouse CD321: Biotin (MBS210455)
anti-CD321 antibody Testing Data image
Testing Data of anti-CD321 antibody
Staining of mouse peripheral blood platelets with Rat anti Mouse CD321 (MBS212720)
anti-CD321 antibody Testing Data image
Testing Data of anti-CD321 antibody
Staining of mouse peripheral blood platelets with Rat anti Mouse CD321
anti-CD321 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for CD321. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,424 Da
NCBI Official Full Name
junctional adhesion molecule A
NCBI Official Synonym Full Names
F11 receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
JAM; Jcam; JAM-1; JAM-A; Jcam1; Ly106; ESTM33; AA638916; 9130004G24
  [Similar Products]
NCBI Protein Information
junctional adhesion molecule A; BV11 antigen; F11 receptor/F11R; junction cell adhesion molecule A; junction cell adhesion molecule1; junctional adhesion molecule 1
UniProt Protein Name
Junctional adhesion molecule A
UniProt Synonym Protein Names
Junctional adhesion molecule 1; JAM-1; CD_antigen: CD321
UniProt Gene Name
UniProt Synonym Gene Names
Jam1; Jcam; Jcam1; JAM-A; JAM-1  [Similar Products]
UniProt Entry Name
JAM1_MOUSE
UniProt Comments for CD321
JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily.

Protein type: Cell adhesion; Membrane protein, integral

Cellular Component: microtubule cytoskeleton; tight junction; membrane; integral to membrane; plasma membrane; cytoplasmic vesicle; intercellular junction; cell junction

Molecular Function: protein binding; PDZ domain binding

Biological Process: epithelial cell differentiation; viral reproduction; actomyosin structure organization and biogenesis; cell adhesion; positive regulation of blood pressure; intestinal absorption
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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