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anti-CD36 antibody :: Rat CD36 Monoclonal Antibody

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Catalog # MBS217381
Unit / Price
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  0.5 mg  /  $675 +1 FREE 8GB USB
Product Name

CD36, Monoclonal Antibody

Full Product Name

RAT ANTI MOUSE CD36:Low Endotoxin

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q08857
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
MF3
Host
Rat
Form/Format
Low Endotoxin
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Preparation
Purified IgG prepared by affinity chromatography on Protein G
Immunogen
IL-4 treated murine thioglycollate-elicited peritoneal macrophages.
Fusion Partners
Target Species
Mouse
Preparation and Storage
Store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-CD36 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD36 antibody
Rat anti Mouse CD36 antibody, clone MF3 recognizes mouse CD36, an 85kD transmembrane glycoprotein which is primarily expressed on platelets, monocytes/macrophages, smooth muscle and endothelial cells. The CD36 molecule is type B scavenger receptor, which binds to multiple ligands including thrombospondin, anionic phospholipids, oxidized low density lipoproteins and long chain fatty acids. CD36 has diverse functions and is reported to play a role in innate immunity, platelet adhesion/aggregation and long chain fatty acid transport. The CD36 molecule also directly mediates cytoadhesion of erythrocytes infected with Plasmodium falciparum, and may be involved in the development of atherosclerotic lesions and the formation of foam cells. Rat anti Mouse CD36 antibody, clone MF3 has been shown to inhibit IL-4 induced thioglycollate-elicited peritoneal macrophage fusion and significantly block IL-4/GM-CSF-induced bone-marrorw derived macrophage fusion.
Applications Tested/Suitable for anti-CD36 antibody
Flow cytometry (FC/FACS), Functional Assays (FN), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-CD36 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.

Testing Data of anti-CD36 antibody
Staining of Mouse peripheral blood platelets with Rat anti Mouse CD36:Alexa Fluor ?647 (MBS217380A647)
anti-CD36 antibody Testing Data image
Testing Data of anti-CD36 antibody
Staining of mouse peripheral blood platelets with Rat anti Mouse CD36 (MBS217382)
anti-CD36 antibody Testing Data image
Testing Data of anti-CD36 antibody
Staining of Mouse peripheral blood platelets with Rat anti Mouse CD36 Alexa Fluor 488 (MBS217380A488)
anti-CD36 antibody Testing Data image
Testing Data of anti-CD36 antibody
Staining of mouse peripheral blood platelets with Rat anti Mouse CD36:Low Endotoxin
anti-CD36 antibody Testing Data image
Testing Data of anti-CD36 antibody
Staining of mouse peripheral blood platelets with Rat anti Mouse CD36 (MBS217380)
anti-CD36 antibody Testing Data image
Testing Data of anti-CD36 antibody
Staining of mouse peripheral blood platelets with Rat anti Mouse CD36:FITC (MBS219350)
anti-CD36 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for CD36. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
52,698 Da
NCBI Official Full Name
platelet glycoprotein 4
NCBI Official Synonym Full Names
CD36 antigen
NCBI Official Symbol
NCBI Official Synonym Symbols
FAT; GPIV; Scarb3
  [Similar Products]
NCBI Protein Information
platelet glycoprotein 4; GPIIIB; PAS IV; PAS-4; fatty acid translocase; glycoprotein IIIb; platelet glycoprotein IV
UniProt Protein Name
Platelet glycoprotein 4
UniProt Synonym Protein Names
Glycoprotein IIIb; GPIIIB; PAS IV; PAS-4; Platelet glycoprotein IV; GPIV; CD_antigen: CD36
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
GPIIIB; GPIV  [Similar Products]
UniProt Entry Name
CD36_MOUSE
UniProt Comments for CD36
CD36: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cell adhesion

Cellular Component: Golgi apparatus; extracellular space; cell surface; protein complex; mitochondrion; intracellular membrane-bound organelle; endoplasmic reticulum; integral to membrane; caveola; lipid raft; membrane; apical part of cell; plasma membrane; intracellular; sarcolemma; external side of plasma membrane

Molecular Function: low-density lipoprotein receptor activity; protein binding; transforming growth factor beta binding; low-density lipoprotein binding; high-density lipoprotein binding; lipid binding

Biological Process: positive regulation of blood coagulation; cGMP-mediated signaling; positive regulation of interleukin-12 production; phagocytosis, recognition; negative regulation of transcription from RNA polymerase II promoter; pattern recognition receptor signaling pathway; fatty acid metabolic process; negative regulation of transcription factor import into nucleus; signal transduction; low density lipoprotein mediated signaling; sequestering of lipid; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; transport; positive regulation of cell-matrix adhesion; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; cell adhesion; long-chain fatty acid transport; receptor-mediated endocytosis; cholesterol transport; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of systemic arterial blood pressure; positive regulation of interleukin-6 production; long-chain fatty acid metabolic process; positive regulation of tumor necrosis factor production; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; negative regulation of angiogenesis; triacylglycerol metabolic process; lipoprotein transport; response to mechanical stimulus; fatty acid oxidation; positive regulation of phagocytosis, engulfment; nitric oxide mediated signal transduction; plasma membrane long-chain fatty acid transport; fatty acid transport; apoptotic cell clearance; positive regulation of cytokine secretion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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