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anti-CD41 antibody :: Rat CD41 Monoclonal Antibody

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Catalog # MBS210420
Unit / Price
  0.1 mg  /  $265 +1 FREE 8GB USB
Testing Data
Product Name

CD41, Monoclonal Antibody

Also Known As

RAT ANTI MOUSE CD41:Biotin

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1033
3D Structure
ModBase 3D Structure for Q9QUM0
Clonality
Monoclonal
Isotype
IgG1
Clone Number
MWReg30
Host
Rat
Form/Format
Biotin
Purified IgG conjugated to Biotin - liquid
Concentration
IgG concentration 0.1 mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
Preparation
Buffer Solution
Phosphate buffered saline
Target Species
Mouse
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-CD41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD41 antibody
Rat anti Mouse CD41 antibody, clone MWReg30 recognizes the mouse integrin alpha IIb subunit CD41. CD41 is a ~125kDa single pass type 1 transmembrane glycoprotein expressed by platelets, megakaryocytes (Zhang et al. 2007), mast cells (Berlanga et al. 2005)and hematopoietic progenitors (Mitjavila-Garcia et al. 2002). CD41 forms a heterodimer with CD61. The CD41/CD61 complex is important for platelet adhesion and aggregation (Patel et al. 2003) acting as a receptor for many extracellular matrix proteins including fibronectin, thrombospondin and vitronectin (Weisel et al. 1992). Rat anti mouse CD41, clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo (Nieswandt et al. 1999).
Applications Tested/Suitable for anti-CD41 antibody
Flow cytometry (FC/FACS)
Application Notes for anti-CD41 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR.
Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/10

Testing Data of anti-CD41 antibody
Staining of mouse peripheral blood with Rat anti Mouse CD41 (MBS212608). Platelets stain strongly for CD41
anti-CD41 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for CD41. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
112,678 Da
NCBI Official Full Name
integrin alpha-IIb
NCBI Official Synonym Full Names
integrin alpha 2b
NCBI Official Symbol
Itga2b  [Similar Products]
NCBI Official Synonym Symbols
CD41; CD41B; GpIIb; AI172977; alphaIIb
  [Similar Products]
NCBI Protein Information
integrin alpha-IIb; GP IIb; GPalpha IIb; platelet glycoprotein IIb of IIb/II Ia complex; platelet membrane glycoprotein IIb
UniProt Protein Name
Integrin alpha-IIb
UniProt Synonym Protein Names
GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD_antigen: CD41Cleaved into the following 2 chains:Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain
UniProt Gene Name
Itga2b  [Similar Products]
UniProt Synonym Gene Names
GPIIb  [Similar Products]
UniProt Entry Name
ITA2B_MOUSE
UniProt Comments for CD41
ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral

Cellular Component: cell surface; focal adhesion; membrane; integral to membrane; integrin complex; external side of plasma membrane

Molecular Function: identical protein binding; extracellular matrix binding; metal ion binding

Biological Process: integrin-mediated signaling pathway; positive regulation of leukocyte migration; cell-matrix adhesion; cell adhesion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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