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anti-CD44 antibody :: Mouse CD44 Monoclonal Antibody

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Catalog # MBS213108
Unit / Price
  0.25 mg  /  $345 +1 FREE 8GB USB
Product Name

CD44, Monoclonal Antibody

Also Known As

MOUSE ANTI RAT CD44

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
364
3D Structure
ModBase 3D Structure for P26051
Clonality
Monoclonal
Isotype
IgG1
Clone Number
OX-50
Host
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium Azide
Preparation
Buffer Solution
Phosphate buffered saline
Target Species
Rat
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-CD44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD44 antibody
Mouse anti Rat CD44 antibody, clone OX-50 recognizes the rat CD44 cell surface antigen, expressed by T cells, B cells, macrophages and thymocytes. CD44 is a glycoprotein of 85kD, with expression being increased following activation.
Applications Tested/Suitable for anti-CD44 antibody
Immunohistology Frozen*, Flow cytometry (FC/FACS)
Application Notes for anti-CD44 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Immunohistology - Frozen: Application Note: The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. MyBioSource recommends the use of acetone fixation for frozen sections.
Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100

Testing Data of anti-CD44 antibody
Staining of rat spleen cells with Mouse anti Rat CD44:FITC (MBS211070)
anti-CD44 antibody Testing Data image
Testing Data of anti-CD44 antibody
Staining of rat spleen cells with Mouse anti Rat CD44: FITC (MBS211069)
anti-CD44 antibody Testing Data image
Testing Data of anti-CD44 antibody
Staining of rat spleen cells with Mouse anti Rat CD44 (MBS219235)
anti-CD44 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for CD44. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,794 Da
NCBI Official Full Name
CD44 antigen isoform X7
NCBI Official Synonym Full Names
CD44 molecule (Indian blood group)
NCBI Official Symbol
NCBI Official Synonym Symbols
CD44A; METAA; RHAMM
  [Similar Products]
NCBI Protein Information
CD44 antigen; Cell surface glycoprotein CD44 (hyaluronate binding protein); ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; PGP-1; PGP-I; extracellular matrix receptor III; hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; phagocytic glycoprotein I
UniProt Protein Name
CD44 antigen
UniProt Synonym Protein Names
Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD_antigen: CD44
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
ECMR-III; PGP-1; PGP-I  [Similar Products]
UniProt Entry Name
CD44_RAT
NCBI Summary for CD44
adhesion molecule involved in migration, cell fusion and resportion in osteoclasts that also plays a role in cellular metastasis [RGD, Feb 2006]
UniProt Comments for CD44
CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Cell adhesion

Cellular Component: Golgi apparatus; focal adhesion; protein complex; cell surface; basolateral plasma membrane; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; nucleus; external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; transmembrane receptor activity; cytokine binding; hyaluronic acid binding; phosphoprotein binding; protein kinase binding; hyalurononglucosaminidase activity; epidermal growth factor receptor binding

Biological Process: cell migration; Wnt receptor signaling pathway; positive regulation of heterotypic cell-cell adhesion; positive regulation of neutrophil apoptosis; negative regulation of caspase activity; response to organic cyclic substance; positive regulation of peptidyl-serine phosphorylation; blood vessel maturation; response to vitamin A; hyaluronan catabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mature B cell apoptosis; ureteric bud branching; cartilage development; regulation of cell growth; inflammatory response; cell adhesion; healing during inflammatory response; neurite development; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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