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anti-CD44v4 antibody :: Rat CD44v4 Monoclonal Antibody

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Catalog # MBS212425
Unit / Price
  0.1 mg  /  $370 +1 FREE 8GB USB
anti-CD44v4 antibody
Product Name

CD44v4, Monoclonal Antibody

Also Known As

RAT ANTI MOUSE CD44v4

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
365
3D Structure
ModBase 3D Structure for P15379
Clonality
Monoclonal
Isotype
IgG1
Clone Number
10D1
Host
Rat
Specificity
This item specifically recognises an epitope encoded by exon v4 on the variant portion of mouse CD44.
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 0.5mg/ml (lot specific)
Perservative Stabilisers
0.01% Thiomersal
Preparation
Immunogen
Recombinant CD44v4 fusion protein
Fusion Partners
Target Species
Mouse
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-CD44v4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD44v4 antibody
MBS212425 specifically recognises an epitope encoded by exon v4 on the variant portion of mouse CD44.
Applications Tested/Suitable for anti-CD44v4 antibody
Immunohistology Frozen, ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for CD44v4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,999 Da
NCBI Official Full Name
CD44 antigen isoform c
NCBI Official Synonym Full Names
CD44 antigen
NCBI Official Symbol
NCBI Official Synonym Symbols
Ly-24; Pgp-1; HERMES; AU023126; AW121933; AW146109
  [Similar Products]
NCBI Protein Information
CD44 antigen; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; PGP-I; extracellular matrix receptor III; hermes antigen; hyaluronate receptor; lymphocyte antigen 24; phagocytic glycoprotein 1; phagocytic glycoprotein I
UniProt Protein Name
CD44 antigen
UniProt Synonym Protein Names
Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; Lymphocyte antigen 24; Ly-24; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD_antigen: CD44
UniProt Gene Name
UniProt Synonym Gene Names
Ly-24; ECMR-III; Ly-24; PGP-1; PGP-I  [Similar Products]
UniProt Entry Name
CD44_MOUSE
UniProt Comments for CD44v4
CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc.

Cellular Component: Golgi apparatus; cell surface; protein complex; focal adhesion; membrane; basolateral plasma membrane; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; nucleus; external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; cytokine binding; hyaluronic acid binding; phosphoprotein binding; protein kinase binding; epidermal growth factor receptor binding; hyalurononglucosaminidase activity

Biological Process: cell migration; positive regulation of heterotypic cell-cell adhesion; Wnt receptor signaling pathway; positive regulation of neutrophil apoptosis; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; hyaluronan catabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mature B cell apoptosis; ureteric bud branching; regulation of cell growth; cell adhesion; healing during inflammatory response; neurite development; positive regulation of adaptive immune response; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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