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anti-CD59 antibody :: Mouse CD59 Monoclonal Antibody

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Catalog # MBS212287
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anti-CD59 antibody
Product Name

CD59, Monoclonal Antibody

Full Product Name

MOUSE ANTI RAT CD59

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P27274
Clonality
Monoclonal
Isotype
IgG1
Clone Number
1B4
Host
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 0.5 mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium Azide
Preparation
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse P3.X63.Ag8.653 myeloma cell line.
Buffer Solution
Target Species
Rat
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-CD59 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD59 antibody
Mouse anti Rat CD59 antibody, clone 1B4 recognizes the rat CD59 cell surface antigen, a 21kDa glycoprotein expressed by erythrocytes. CD59 acts to inhibit the membrane attack complex of complement. Mouse anti Rat CD59 antibody, clone 1B4 recognizes the same, or a closely related epitope to antibody clone 6D1.
Applications Tested/Suitable for anti-CD59 antibody
Flow cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-CD59 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Maximum Dilution: 10ug/ml
Western Blotting: Maximum Dilution: Non-reducing conditions
NCBI/Uniprot data below describe general gene information for CD59. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
13,790 Da
NCBI Official Full Name
CD59 glycoprotein
NCBI Official Synonym Full Names
CD59 molecule, complement regulatory protein
NCBI Official Symbol
NCBI Official Synonym Symbols
Cd59a; Cd59b; MACIF; MACIP; MAC-IP
  [Similar Products]
NCBI Protein Information
CD59 glycoprotein; CD59 antigen; CD59b moleucle, complement regulatory protein; Cb59b molecule; MAC-inhibitory protein; membrane attack complex inhibition factor; protectin
UniProt Protein Name
CD59 glycoprotein
UniProt Synonym Protein Names
MAC-inhibitory protein; MAC-IP; Membrane attack complex inhibition factor; MACIF; Protectin; CD_antigen: CD59
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
MAC-IP; MACIF  [Similar Products]
UniProt Entry Name
CD59_RAT
NCBI Summary for CD59
may play a role in regulation of complement; may bind complement proteins C8 and C9 [RGD, Feb 2006]
UniProt Comments for CD59
CD59: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

Protein type: Membrane protein, GPI anchor

Cellular Component: anchored to external side of plasma membrane; extracellular space; compact myelin; cell surface; focal adhesion; plasma membrane; sarcolemma; vesicle

Molecular Function: complement binding

Biological Process: negative regulation of cytolysis; cell surface receptor linked signal transduction; negative regulation of complement activation; regulation of complement activation; negative regulation of activation of membrane attack complex; positive regulation of T cell proliferation; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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