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anti-CD68 antibody :: Mouse CD68 Monoclonal Antibody

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Catalog # MBS215240
Unit / Price
  0.1 mL  /  $210 +1 FREE 8GB USB
anti-CD68 antibody
Product Name

CD68, Monoclonal Antibody

Popular Item
Full Product Name

MOUSE ANTI HUMAN CD68

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
153634
3D Structure
ModBase 3D Structure for P34810
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
514H12
Host
Mouse
Form/Format
Tissue Culture Supernatant - liquid
Perservative Stabilisers
0.09% Sodium Azide
Immunogen
Fusion protein corresponding to external domain of human CD68
Histology Positive Control Tissue
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
Other Notes
Small volumes of anti-CD68 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD68 antibody
Mouse anti Human CD68 antibody, clone 514H12 recognizes the human CD68 cell surface antigen, a 110kDa glycoprotein primarily expressed by macrophages and monocytes.
Applications Tested/Suitable for anti-CD68 antibody
Immunohistology Frozen, Immunofluorescence (IF), Immunohistology Paraffin*
Application Notes for anti-CD68 antibody
Immunohistology - Paraffin: Minimum Dilution: 1/40; Maximum Dilution: 1/80; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. EDTA buffer pH 8.0 is recommended for this purpose. N.B. The epitope recognised by clone 514H12 is sensitive to peroxide. It is therefore recommended that any peroxidase-blocking steps be performed after incubation with this antibody.
NCBI/Uniprot data below describe general gene information for CD68. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,654 Da
NCBI Official Full Name
macrosialin isoform B
NCBI Official Synonym Full Names
CD68 molecule
NCBI Official Symbol
NCBI Official Synonym Symbols
GP110; LAMP4; SCARD1
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NCBI Protein Information
macrosialin; CD68 antigen; macrophage antigen CD68; scavenger receptor class D, member 1
UniProt Protein Name
Macrosialin
UniProt Synonym Protein Names
Gp110; CD_antigen: CD68
Protein Family
UniProt Gene Name
UniProt Entry Name
CD68_HUMAN
NCBI Summary for CD68
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for CD68
CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: membrane; lysosomal membrane; integral to membrane; plasma membrane; endosome membrane
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-CD68 antibody
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