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anti-CD75s antibody :: Mouse CD75s Monoclonal Antibody

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Catalog # MBS219339
Unit / Price
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  0.1 mg  /  $675 +1 FREE 8GB USB
anti-CD75s antibody
Product Name

CD75s, Monoclonal Antibody

Full Product Name

MOUSE ANTI HUMAN CD75s

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
109675
3D Structure
ModBase 3D Structure for P15907
Clonality
Monoclonal
Isotype
IgM
Clone Number
LN-1
Host
Mouse
Form/Format
Purified
Purified IgM - liquid
Concentration
IgM concentration 0.1mg/ml (lot specific)
Perservative Stabilisers
0.05% Sodium Azide
Immunogen
Human lymphocytes and SU-DHL4 cell line
Histology Positive Control Tissue
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-CD75s antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD75s antibody
Mouse anti Human CD75s antibody, clone LN-1 recognizes the human CD75s cell surface antigen, an alpha2,6 - sialylated carbohydrate epitope expressed by mature B cells (especially germinal centre B cells), red blood cells and some epithelial cells.
Applications Tested/Suitable for anti-CD75s antibody
Immunohistology Frozen, Flow cytometry (FC/FACS), Immunohistology Paraffin*
Application Notes for anti-CD75s antibody
Immunohistology - Frozen: Minimum Dilution: 1/10; Maximum Dilution: 1/100;
Immunohistology - Paraffin: Application Note: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.
NCBI/Uniprot data below describe general gene information for CD75s. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,764 Da
NCBI Official Full Name
beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
NCBI Official Synonym Full Names
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
NCBI Official Symbol
ST6GAL1  [Similar Products]
NCBI Official Synonym Symbols
ST6N; SIAT1; ST6GalI
  [Similar Products]
NCBI Protein Information
beta-galactoside alpha-2,6-sialyltransferase 1; B-cell antigen CD75; CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; alpha 2,6-ST 1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase)
UniProt Protein Name
Beta-galactoside alpha-2,6-sialyltransferase 1
UniProt Synonym Protein Names
B-cell antigen CD75; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1
UniProt Gene Name
ST6GAL1  [Similar Products]
UniProt Synonym Gene Names
SIAT1; Alpha 2,6-ST 1; ST6GalI  [Similar Products]
UniProt Entry Name
SIAT1_HUMAN
NCBI Summary for CD75s
This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009]
UniProt Comments for CD75s
SIAT1: a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. Is normally found in the trans cisternae of the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found.

Protein type: Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; EC 2.4.99.1; Transferase

Chromosomal Location of Human Ortholog: 3q27.3

Cellular Component: Golgi membrane; integral to Golgi membrane

Molecular Function: sialyltransferase activity; beta-galactoside alpha-2,6-sialyltransferase activity

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; O-glycan processing; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; humoral immune response; N-acetylneuraminate metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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