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anti-CD79B antibody :: Mouse CD79b Preservative Free Monoclonal Antibody

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Catalog # MBS603208
Unit / Price
  0.1 mg  /  $565 +1 FREE 8GB USB
anti-CD79B antibody
Product Name

CD79b Preservative Free, Monoclonal Antibody

Popular Item
Also Known As

CD79b Preservative Free (BCR-Ig beta)

Product Synonym Names
Anti -CD79b Preservative Free (BCR-Ig beta)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (62006098..62009704, complement). Location: 17q23
OMIM
147245
3D Structure
ModBase 3D Structure for P40259
Clonality
Monoclonal
Isotype
IgG1
Clone Number
7H118
Host
Mouse
Specificity
Recognizes the extracellular part of the BCR complex beta chain (CD79b) which has a molecular weight of approximately 38kD.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2 No preservatives.
Immunogen
Membrane preparation of human B prolymphocytic leukemia cells
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-CD79B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD79B antibody
Human CD79b is the B cell antigen receptor Igb chain (BCR-Igb) which associates with B cell antigen receptor Ig a chain to form a functional heterodimer that interacts with membrane immunoglobulin (mIg). The mIgM component binds antigen and the Iga/Igb heterodimer transduces signals.
Product Categories/Family for anti-CD79B antibody
Applications Tested/Suitable for anti-CD79B antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-CD79B antibody
Suitable for use in Flow Cytometry, Immunoprecipitation, Immunohistochemistry and Western Blot.
NCBI/Uniprot data below describe general gene information for CD79B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,048 Da[Similar Products]
NCBI Official Full Name
CD79b
NCBI Official Synonym Full Names
CD79b molecule, immunoglobulin-associated beta
NCBI Official Symbol
CD79B  [Similar Products]
NCBI Official Synonym Symbols
B29; IGB; AGM6
  [Similar Products]
NCBI Protein Information
B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta)
UniProt Protein Name
B-cell antigen receptor complex-associated protein beta chain
UniProt Synonym Protein Names
B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein
UniProt Gene Name
CD79B  [Similar Products]
UniProt Synonym Gene Names
B29; IGB  [Similar Products]
UniProt Entry Name
CD79B_HUMAN
NCBI Summary for CD79B
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
UniProt Comments for CD79B
Ig-beta: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23

Cellular Component: nucleoplasm; Golgi apparatus; integral to plasma membrane; cytoplasm; plasma membrane; B cell receptor complex; external side of plasma membrane

Molecular Function: transmembrane receptor activity

Biological Process: B cell receptor signaling pathway; immune response; signal transduction

Disease: Agammaglobulinemia 6, Autosomal Recessive
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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