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anti-Cdk6 antibody :: Mouse Cdk6 Monoclonal Antibody

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Catalog # MBS212445
Unit / Price
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  0.1 mg  /  $570 +1 FREE 8GB USB
Testing Data
Product Name

Cdk6, Monoclonal Antibody

Full Product Name

MOUSE ANTI HUMAN Cdk6

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
603368
3D Structure
ModBase 3D Structure for Q00534
Clonality
Monoclonal
Isotype
IgG1
Clone Number
DCS-83.1
Host
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Perservative Stabilisers
0.08% Sodium Azide
Preparation
Histology Positive Control Tissue
U-2-OS sarcoma cell line
Buffer Solution
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-Cdk6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Cdk6 antibody
Mouse anti Human Cdk6 antibody, clone DCS-83 recognizes the human cyclin dependent kinase 6, also known as Cdk6 or Serine/threonine-protein kinase PLSTIRE. Cdk6 is a 326 amino acid member of the CDC2/CDKX subfamily containing a single protein kinase domain. Pck6 migrates at ~37kDa in Western blotting under reducing conditions. Cdk6 pays an important role in cell cycle progression from the G1 to S phase (Sun et al. 2008) Mouse anti Human Cdk6, clone DCS83 additionally recognizes both the rat and mouse homologs of Human Cdk6. and has been successfully used for immunoprecipitation and immunofluorescesnce on acetone/methanol fixed cell preparations (Lukas et al. 1999).
Applications Tested/Suitable for anti-Cdk6 antibody
Immunohistology Frozen, Immunoprecipitation (IP), Western Blot (WB)

Testing Data of anti-Cdk6 antibody
Western blot analysis of Molt-4 acute lymphoblastic derived T-cell lysate probed with Mouse anti Human Cdk6 antibody followed by HRP conjugated Goat anti Mouse IgG, visualized by chemiluminescence
anti-Cdk6 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for Cdk6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,938 Da
NCBI Official Full Name
cyclin-dependent kinase 6
NCBI Official Synonym Full Names
cyclin-dependent kinase 6
NCBI Official Symbol
NCBI Official Synonym Symbols
MCPH12; PLSTIRE
  [Similar Products]
NCBI Protein Information
cyclin-dependent kinase 6; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE
UniProt Protein Name
Cyclin-dependent kinase 6
UniProt Synonym Protein Names
Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CDKN6  [Similar Products]
UniProt Entry Name
CDK6_HUMAN
NCBI Summary for Cdk6
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
UniProt Comments for Cdk6
CDK6: a protein kinase of the CDK family. Important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. Phosphorylates and regulates the activity of the Rb tumor suppressor protein. Overexpressed and/or disrupted by translocation in leukemias, lymphomas and other cancers and amplified in gliomas and rodent cancers.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Cell cycle regulation; EC 2.7.11.22; Protein kinase, CMGC; CMGC group; CDK family; CDK/CDK4 subfamily; CDK4 subfamily

Chromosomal Location of Human Ortholog: 7q21-q22

Cellular Component: nucleoplasm; ruffle; centrosome; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; nucleus; cytosol

Molecular Function: protein binding; cyclin binding; cyclin-dependent protein kinase activity; ATP binding

Biological Process: Notch signaling pathway; negative regulation of myeloid cell differentiation; dentate gyrus development; gliogenesis; response to virus; T cell differentiation in the thymus; astrocyte development; protein amino acid phosphorylation; negative regulation of cell cycle; regulation of erythrocyte differentiation; negative regulation of cell proliferation; positive regulation of fibroblast proliferation; negative regulation of cell differentiation; generation of neurons; cell division; regulation of gene expression; cell dedifferentiation; negative regulation of osteoblast differentiation; mitotic cell cycle; positive regulation of cell-matrix adhesion; cell cycle arrest; lateral ventricle development; G1/S transition of mitotic cell cycle; negative regulation of epithelial cell proliferation

Disease: Microcephaly 12, Primary, Autosomal Recessive
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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