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anti-CLDN3 antibody :: claudin-3 Monoclonal Antibody

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Catalog # MBS313135
Unit / Price
  1 mg  /  $730 +1 FREE 8GB USB
anti-CLDN3 antibody
Product Name

claudin-3 (CLDN3), Monoclonal Antibody

Also Known As

MAb to Claudin-3 (aa 30-80)

Product Synonym Names
Monoclonal Antibody to Human Claudin-3, amino acids 30-80.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
220
Chromosome Location
Chromosome: 7; NC_000007.13 (73183327..73184600, complement). Location: 7q11.23
OMIM
602910
3D Structure
ModBase 3D Structure for O15551
Clonality
Monoclonal
Isotype
IgG1
Clone Number
B1374M
Host
Host: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from BALB/c mice.; Source: Ascites
Specificity
claudin-3 (a.a. 30-80) (Human Claudin-3, amino acids 30-80.)
Purity/Purification
> 90% pure (SDS-PAGE). Protein A Chromatography
Form/Format
Purified, Liquid
Preservative
0.1% Sodium Azide
Immunogen
Recombinant fusion of Claudin-3 (a.a. 30-80) peptide and human thioredoxin.
Affinity Constant
Not Determined
Buffer
PBS, pH 7.4
Preparation and Storage
Store at 2-8 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CLDN3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CLDN3 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for CLDN3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
23,319 Da[Similar Products]
NCBI Official Full Name
claudin-3
NCBI Official Synonym Full Names
claudin 3
NCBI Official Symbol
CLDN3  [Similar Products]
NCBI Official Synonym Symbols
RVP1; HRVP1; C7orf1; CPE-R2; CPETR2
  [Similar Products]
NCBI Protein Information
claudin-3; CPE-R 2; CPE-receptor 2; ventral prostate.1-like protein; ventral prostate.1 protein homolog; Clostridium perfringens enterotoxin receptor 2
UniProt Protein Name
Claudin-3
UniProt Synonym Protein Names
Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; Rat ventral prostate.1 protein homolog
Protein Family
UniProt Gene Name
CLDN3  [Similar Products]
UniProt Synonym Gene Names
C7orf1; CPETR2; CPE-R 2; CPE-receptor 2; hRVP1  [Similar Products]
UniProt Entry Name
CLD3_HUMAN
NCBI Summary for CLDN3
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
UniProt Comments for CLDN3
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity

By similarity.

Subunit structure: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3

By similarity.

Subcellular location: Cell junction › tight junction

By similarity. Cell membrane; Multi-pass membrane protein

By similarity.

Involvement in disease: Note=CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Sequence similarities: Belongs to the claudin family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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