• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-CYR61 antibody :: Mouse Cysteine-Rich Angiogenic Inducer 61 Monoclonal Antibody

Scan QR to view Datasheet
Catalog # MBS140242
Unit / Price
  0.005 mg  /  $140 +1 FREE 8GB USB
  0.02 mg  /  $205 +1 FREE 8GB USB
  0.1 mg  /  $505 +1 FREE 8GB USB
anti-CYR61 antibody
Product Name

Cysteine-Rich Angiogenic Inducer 61 (CYR61), Monoclonal Antibody

Also Known As

Mouse Anti Human Cysteine-Rich Angiogenic Inducer 61

Product Synonym Names
CYR61 Antibody; Cysteine-Rich Angiogenic Inducer 61, Mouse Anti Human; CYR61; Protein CYR61; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IGF-binding protein 10; IGFBP-10; IBP-10; Protein GIG1; CCN family member 1; CCN1; GIG1; IGFBP10
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
381
OMIM
602369
Clonality
Monoclonal
Isotype
IgG1 heavy chain and kappa light chain
Clone Number
P3H3AT
Host
Mouse
Purity/Purification
CYR61 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Form/Format
1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Sterile Filtered clear solution.
Immunogen
Anti-human CYR61 mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CYR61 amino acids 168-242 purified from E Coli.
Preparation and Storage
For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
Other Notes
Small volumes of anti-CYR61 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CYR61 antibody
Introduction: CYR61 is a growth factor-inducible, immediate-early gene that has multifaceted activities in various cancers. CYR61 is a secreted, cysteine-rich, heparin-binding protein which is encoded by a growth factor-inducible immediate-early gene. Acting as an extracellular, matrix-associated signaling molecule, CYR61 promotes the adhesion of endothelial cells through interaction with integrin and enhances growth factor-induced DNA synthesis in the same cell type.
Applications Tested/Suitable for anti-CYR61 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CYR61 antibody
CYR61 antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot is 1:250~1:1,000 and immunohistochemistry analysis is 1:50~100. Recommended starting dilution for Western blot is 1:250 and Immunohistochemistry is 1:50.
NCBI/Uniprot data below describe general gene information for CYR61. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,027 Da
NCBI Official Full Name
protein CYR61
NCBI Official Synonym Full Names
cysteine-rich, angiogenic inducer, 61
NCBI Official Symbol
CYR61  [Similar Products]
NCBI Official Synonym Symbols
CCN1; GIG1; IGFBP10
  [Similar Products]
NCBI Protein Information
protein CYR61; CCN family member 1; IBP-10; IGF-binding protein 10; IGFBP-10; cysteine-rich heparin-binding protein 61; cysteine-rich, anigogenic inducer, 61; insulin-like growth factor-binding protein 10
UniProt Protein Name
Protein CYR61
UniProt Synonym Protein Names
CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1
Protein Family
UniProt Gene Name
CYR61  [Similar Products]
UniProt Synonym Gene Names
CCN1; GIG1; IGFBP10; IBP-10; IGF-binding protein 10; IGFBP-10  [Similar Products]
UniProt Entry Name
CYR61_HUMAN
NCBI Summary for CYR61
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
UniProt Comments for CYR61
CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: integrin binding; heparin binding; insulin-like growth factor binding; extracellular matrix binding

Biological Process: anatomical structure morphogenesis; extracellular matrix organization and biogenesis; positive regulation of caspase activity; chemotaxis; intussusceptive angiogenesis; osteoblast differentiation; positive regulation of osteoblast differentiation; cell proliferation; cell-cell signaling; positive regulation of protein kinase activity; positive regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; regulation of cell growth; cell adhesion; positive regulation of BMP signaling pathway; negative regulation of apoptosis; positive regulation of cell migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000