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anti-ELN antibody :: Mouse Elastin (ELN) Monoclonal Antibody

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Catalog # MBS2012716 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
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anti-ELN antibody
Product Name

Elastin (ELN), Monoclonal Antibody

Popular Item
Also Known As

Monoclonal Antibody to Elastin (ELN)

Product Gene Name
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS2012716 COA
MBS2012716 Technical Datasheet
Chromosome Location
Chromosome: 7; NC_000007.13 (73442119..73484237). Location: 7q11.23
OMIM
123700
3D Structure
ModBase 3D Structure for P15502
Clonality
Monoclonal
Isotype
IgG2b Kappa
Clone Number
6-1#
Host
Mouse
Purity/Purification
Protein A/G Affinity Chromatography.
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Concentration
0.88 mg/ml (lot specific)
Organism Species
Rattus norvegicus (Rat)
Source
Monoclonal antibody preparation
Label
FITC
Traits
Liquid
Immunogen
Recombinant GAD2 (Met1~Ala150) expressed in E.coli.
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 4°C for frequent use.
Aliquot and store at -20°C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.
Other Notes
Small volumes of anti-ELN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ELN antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunprecipitation (IP).
Application Notes for anti-ELN antibody
Western blotting: 0.5-2 ug/mL;1:440-1750
Immunohistochemistry: 5-20 ug/mL;1:44-175
Immunocytochemistry: 5-20 ug/mL;1:44-175

Optimal working dilutions must be determined by end user.
NCBI/Uniprot data below describe general gene information for ELN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
elastin isoform m
NCBI Official Synonym Full Names
elastin
NCBI Official Symbol
NCBI Official Synonym Symbols
WS; WBS; SVAS
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NCBI Protein Information
elastin; tropoelastin
UniProt Protein Name
Elastin
UniProt Synonym Protein Names
Tropoelastin
Protein Family
UniProt Gene Name
UniProt Entry Name
ELN_HUMAN
NCBI Summary for ELN
This gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ELN
elastin: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Defects in ELN are the cause of cutis laxa, autosomal dominant, type 1 (ADCL1). A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Defects in ELN are the cause of supravalvular aortic stenosis (SVAS). SVAS is a congenital narrowing of the ascending aorta which can occur sporadically, as an autosomal dominant condition, or as one component of Williams-Beuren syndrome. ELN is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of ELN may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. Belongs to the elastin family. 13 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: proteinaceous extracellular matrix; extracellular region

Molecular Function: protein binding; extracellular matrix structural constituent

Biological Process: extracellular matrix disassembly; cell proliferation; organ morphogenesis; extracellular matrix organization and biogenesis; blood circulation; respiratory gaseous exchange

Disease: Cutis Laxa, Autosomal Dominant 1; Williams-beuren Syndrome; Supravalvular Aortic Stenosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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