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anti-Esr2 antibody :: Mouse Estrogen Receptor beta Monoclonal Antibody

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Catalog # MBS190148
Unit / Price
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  0.1 mg  /  $425 +1 FREE 8GB USB
anti-Esr2 antibody
Product Name

Estrogen Receptor beta (Esr2), Monoclonal Antibody

Full Product Name

Estrogen Receptor- beta Monoclonal Antibody

Product Synonym Names
Anti-Estrogen Receptor beta; Estrogen Receptor-beta
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_005105.2 (98691167..98775299, complement). Location: 6q24
3D Structure
ModBase 3D Structure for Q59IV8
Clonality
Monoclonal
Isotype
IgG2b kappa
Host
Mouse
Specificity
Anti-Estrogen Receptor beta [Murine MAb to fusion protein corresponding to aa 1-153 of human estrogen receptor-beta, a member of the steroid family of nuclear receptors.]
This antibody recognizes human ER- beta , a novel receptor (approx. 52 kD) recently isolated from testis. The size and structure of ER- beta are very similar to ER- alpha with the ligand and DNA binding domains being highly conserved. The N-terminus of each receptor, which serves as their transactivation domain, are significantly different. Like ER- alpha , ER- beta binds to estrogen with a high affinity and regulates estrogen-specific gene activation through direct interaction with estrogen response elements
Form/Format
100 ug Protein G-purified antibody in PBS, pH 7.4
Antigen
6-His fusion protein containing the region encoding aa 1-153of human estrogen receptor- beta (ER- beta ) expressed in E. coli.
Stabilizer
None
Preservatives
None. Available on request.
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
This antibody is stable for at least one (1) year at -70 degree C. Avoid multiple freeze thaw cycles.
Other Notes
Small volumes of anti-Esr2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-Esr2 antibody
Applications Tested/Suitable for anti-Esr2 antibody
Immunoblot
Application Notes for anti-Esr2 antibody
Immunoblotting: use at 1-5 ug/ml.
Positive controls: Native receptor from human thymus, spleen, ovary, and testisor recombinant protein.
NCBI/Uniprot data below describe general gene information for Esr2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
63,322 Da[Similar Products]
NCBI Official Full Name
estrogen receptor beta
NCBI Official Synonym Full Names
estrogen receptor 2 (ER beta)
NCBI Official Symbol
NCBI Official Synonym Symbols
Erb2; ERbeta; ER-beta
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NCBI Protein Information
estrogen receptor beta; estrogen receptor 2 beta; nuclear receptor subfamily 3 group A member 2
UniProt Protein Name
Estrogen receptor 2 beta, isoform CRA_a
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
Q59IV8_RAT
NCBI Summary for Esr2
binds estrogen and mediates transcriptional activation [RGD]
UniProt Comments for Esr2
ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Protein type: Nuclear receptor; DNA-binding

Cellular Component: neuron projection; cell soma; mitochondrion; perinuclear region of cytoplasm; cytoplasm; plasma membrane; perikaryon; nucleus; cilium

Molecular Function: ligand-dependent nuclear receptor activity; peroxisome proliferator activated receptor binding; estrogen receptor activity; hormone binding; zinc ion binding; estrogen response element binding; drug binding; steroid binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity

Biological Process: prostate gland development; hypothalamus development; behavioral fear response; estrogen receptor signaling pathway; induction of apoptosis by hormones; positive regulation of apoptosis; negative regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; response to hormone stimulus; neuron migration; amygdala development; negative regulation of transcription from RNA polymerase II promoter; response to insecticide; uterus development; response to organic cyclic substance; response to estradiol stimulus; negative regulation of cell proliferation; learning and/or memory; ovarian follicle development; regulation of transcription, DNA-dependent; positive regulation of epidermal growth factor receptor signaling pathway; regulation of neuron apoptosis; cerebellum development; female gonad development; negative regulation of epithelial cell proliferation; response to nutrient levels; steroid hormone receptor signaling pathway; response to drug; transcription, DNA-dependent; male gonad development; vagina development; Sertoli cell proliferation; response to testosterone stimulus; Sertoli cell development; regulation of cell proliferation; response to genistein; response to ethanol; response to estrogen stimulus; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; positive regulation of transcription factor activity; brain development; response to activity; negative regulation of behavior; response to water deprivation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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