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anti-F5 antibody :: Mouse Factor V Heavy Chain Monoclonal Antibody

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Catalog # MBS190149
Unit / Price
  0.25 mg  /  $425 +1 FREE 8GB USB
anti-F5 antibody
Product Name

Factor V Heavy Chain (F5), Monoclonal Antibody

Also Known As

Factor V Heavy Chain Monoclonal Antibody

Product Synonym Names
Anti-Factor V Heavy Chain; Factor V
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (169481192..169555769, complement). Location: 1q23
OMIM
188055
3D Structure
ModBase 3D Structure for P12259
Clonality
Monoclonal
Isotype
IgG1
Host
Mouse
Specificity
Anti-Factor V Heavy Chain [Murine MAb recognizes the heavy chain of human Factor V.]
Form/Format
250 ug Protein G-purified antibody in PBS, pH 7.4.
Antigen
Purified human Factor V.
Activity and Specificity
This antibody reacts with the activation C peptide (mw ~150,000) in the heavy chain of thrombin-cleaved human Factor V. KD = 1.15 x 10^-10 mol/L.
Stabilizer
None
Preservatives
None. Available on request.
Dilutions Instructions
Dilute in PBS or medium that is identical to that used in the assay system.
Preparation and Storage
These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of anti-F5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-F5 antibody
ELISA, Immunohistochemistry
Application Notes for anti-F5 antibody
This antibody may be used in ELISA, immunohistochemistry, and autoradiography. Other applications are under investigation.
NCBI/Uniprot data below describe general gene information for F5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
251,703 Da[Similar Products]
NCBI Official Full Name
factor V precusor
NCBI Official Synonym Full Names
coagulation factor V (proaccelerin, labile factor)
NCBI Official Symbol
NCBI Official Synonym Symbols
FVL; PCCF
  [Similar Products]
NCBI Protein Information
coagulation factor V; factor V Leiden; OTTHUMP00000032547; OTTHUMP00000032548; proaccelerin, labile factor; activated protein c cofactor; coagulation factor V jinjiang A2 domain
UniProt Protein Name
Coagulation factor V
UniProt Synonym Protein Names
Activated protein C cofactor; Proaccelerin, labile factor
Protein Family
UniProt Gene Name
UniProt Entry Name
FA5_HUMAN
NCBI Summary for F5
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq]
UniProt Comments for F5
factor V: Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. Defects in F5 are the cause of factor V deficiency (FA5D); also known as Owren parahemophilia. It is an hemorrhagic diastesis. Defects in F5 are the cause of thrombophilia due to activated protein C resistance (THPH2). THPH2 is a hemostatic disorder due to defective degradation of factor Va by activated protein C. It is characterized by a poor anticoagulant response to activated protein C resulting in tendency to thrombosis. Defects in F5 are a cause of susceptibility to Budd- Chiari syndrome (BDCHS). A syndrome caused by obstruction of hepatic venous outflow involving either the hepatic veins or the terminal segment of the inferior vena cava. Obstructions are generally caused by thrombosis and lead to hepatic congestion and ischemic necrosis. Clinical manifestations observed in the majority of patients include hepatomegaly, right upper quadrant pain and abdominal ascites. Budd-Chiari syndrome is associated with a combination of disease states including primary myeloproliferative syndromes and thrombophilia due to factor V Leiden, protein C deficiency and antithrombin III deficiency. Budd-Chiari syndrome is a rare but typical complication in patients with polycythemia vera. Defects in F5 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in F5 are associated with susceptibility to pregnancy loss, recurrent, type 1 (RPRGL1). RPRGL1 is a common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. Belongs to the multicopper oxidase family.

Protein type: Secreted, signal peptide; Secreted; Protease

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: Golgi apparatus; extracellular space; membrane; endoplasmic reticulum; plasma membrane; extracellular region; vesicle

Molecular Function: protein binding; copper ion binding; serine-type endopeptidase activity

Biological Process: platelet activation; platelet degranulation; blood circulation; proteolysis; blood coagulation

Disease: Thrombophilia Due To Activated Protein C Resistance; Budd-chiari Syndrome; Stroke, Ischemic; Pregnancy Loss, Recurrent, Susceptibility To, 1; Factor V Deficiency
Product References and Citations for anti-F5 antibody
Gewirtz, AM et al. (1986) Blood 67: 1639.

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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