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anti-F7 antibody :: Mouse Factor VII Monoclonal Antibody

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Catalog # MBS530593
Unit / Price
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  0.5 mg  /  $745 +1 FREE 8GB USB
anti-F7 antibody
Product Name

Factor VII (F7), Monoclonal Antibody

Popular Item
Full Product Name

Factor VII antibody

Product Synonym Names
Monoclonal Factor VII; Anti-Factor VII; Complement Factor VII
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
227500
3D Structure
ModBase 3D Structure for P08709
Clonality
Monoclonal
Clone Number
219
Host
Mouse
Species Reactivity
This anitbody is specific for factor VII and does not crossreact with other vitamin K-dependent proteins.
Form/Format
Lyophilized from 10mM Sodium Phosphate, 0.15M NaCl, and 0.01% Sodium Azide, pH 7.4.Reconstitute with DI water to a concentration of 1.0 mg/ml.
Concentration
500ug, lyophilized (lot specific)
Biological Significance
Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class. The main role of factor VII is to initiate the process of coagulation in conjunction with tissue factor (TF/factor III).
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Factor VII antibody was raised in mouse using human factor VII as the immunogen.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
Other Notes
Small volumes of anti-F7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-F7 antibody
Mouse monoclonal Factor VII antibody
Product Categories/Family for anti-F7 antibody
Applications Tested/Suitable for anti-F7 antibody
User optimized
NCBI/Uniprot data below describe general gene information for F7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,320 Da[Similar Products]
NCBI Official Full Name
factor VII
NCBI Official Synonym Full Names
coagulation factor VII (serum prothrombin conversion accelerator)
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
coagulation factor VII
UniProt Protein Name
Coagulation factor VII
UniProt Synonym Protein Names
Proconvertin; Serum prothrombin conversion accelerator; SPCA
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
FA7_HUMAN
NCBI Summary for F7
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
UniProt Comments for F7
F7: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. Defects in F7 are the cause of factor VII deficiency (FA7D). A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC 3.4.21.21; Secreted, signal peptide; Apoptosis; Secreted; Protease

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: extracellular space; endoplasmic reticulum lumen; Golgi lumen; extracellular region; plasma membrane; vesicle

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity; calcium ion binding; glycoprotein binding; receptor binding

Biological Process: circadian rhythm; organ regeneration; positive regulation of positive chemotaxis; positive regulation of blood coagulation; positive regulation of leukocyte chemotaxis; proteolysis; post-translational protein modification; peptidyl-glutamic acid carboxylation; positive regulation of protein kinase B signaling cascade; blood coagulation, extrinsic pathway; cellular protein metabolic process; response to vitamin K; response to estrogen stimulus; blood coagulation; positive regulation of cell migration

Disease: Myocardial Infarction, Susceptibility To; Factor Vii Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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