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anti-FCER1A antibody :: Mouse Fc EPSILON R1 ALPHA Monoclonal Antibody

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Catalog # MBS212740
Unit / Price
  0.2 mg  /  $455 +1 FREE 8GB USB
Testing Data
Product Name

Fc EPSILON R1 ALPHA (FCER1A), Monoclonal Antibody

Also Known As

MOUSE ANTI HUMAN FC EPSILON R1 ALPHA

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
257
OMIM
147140
3D Structure
ModBase 3D Structure for P12319
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
9E1
Host
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium Azide
Preparation
Fusion Partners
Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0-Ag14 myeloma cell line.
Buffer Solution
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-FCER1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FCER1A antibody
Mouse anti Human Fc epsilon R1 alpha antibody, clone 9E1 recognizes the human high affinity Fc receptor for IgE (Fc epsilon R1), which plays a central role in the IgE-mediated allergic response. Fc epsilon R1 consists of four subunits, a high affinity IgE binding alpha subunit, a beta chain and two di-sulphide linked gamma subunits. Clone 9E1 specifically recognizes the extracellular D1 domain of the Fc epsilon R1 alpha chain. Fc epsilon R1 is primarily expressed on mast cells and basophils but expression of Fc epsilon R1 has also been reported on monocytes, Langerhans cells and dendritic cells from patients with atopic diseases.
Applications Tested/Suitable for anti-FCER1A antibody
ELISA (EIA), Flow cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-FCER1A antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul
Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/50

Testing Data of anti-FCER1A antibody
Staining of human peripheral blood cells with Mouse anti Human FC Epsilon R1, showing staining of eosinophils
anti-FCER1A antibody Testing Data image
NCBI/Uniprot data below describe general gene information for FCER1A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
29,596 Da[Similar Products]
NCBI Official Full Name
high affinity immunoglobulin epsilon receptor subunit alpha
NCBI Official Synonym Full Names
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
NCBI Official Symbol
FCER1A  [Similar Products]
NCBI Official Synonym Symbols
FCE1A; FcERI
  [Similar Products]
NCBI Protein Information
high affinity immunoglobulin epsilon receptor subunit alpha; Fc IgE receptor, alpha polypeptide; Fc epsilon RI alpha-chain; Fc-epsilon RI-alpha; high affinity immunoglobulin epsilon receptor alpha-subunit; igE Fc receptor subunit alpha; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
UniProt Protein Name
High affinity immunoglobulin epsilon receptor subunit alpha
UniProt Synonym Protein Names
Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha
UniProt Gene Name
FCER1A  [Similar Products]
UniProt Synonym Gene Names
FCE1A; FcERI  [Similar Products]
UniProt Entry Name
FCERA_HUMAN
NCBI Summary for FCER1A
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
UniProt Comments for FCER1A
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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