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anti-FBLN1 antibody :: Mouse Fibulin 1 (FBLN1) Monoclonal Antibody

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Catalog # MBS2085940 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
Scan QR to view Datasheet
  0.01 mg  /  $100 +1 FREE 8GB USB
  0.02 mg  /  $110 +1 FREE 8GB USB
  0.05 mg  /  $140 +1 FREE 8GB USB
  0.1 mg  /  $175 +1 FREE 8GB USB
  0.2 mg  /  $225 +1 FREE 8GB USB
  1 mg  /  $505 +1 FREE 8GB USB
Product Name

Fibulin 1 (FBLN1), Monoclonal Antibody

Popular Item
Full Product Name

Monoclonal Antibody to Fibulin 1 (FBLN1)

Matching Pairs
Matching Pairs
Unconjugated Antibody: Fibulin 1 (FBLN1) (MBS2085940)
APC-CY7 Conjugated Antibody: Fibulin 1 (FBLN1) (MBS2065944)
Matching Pairs
Unconjugated Antibody: Fibulin 1 (FBLN1) (MBS2085940)
PE Conjugated Antibody: Fibulin 1 (FBLN1) (MBS2065946)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS2085940 Technical Datasheet
OMIM
X53741 mRNA
3D Structure
ModBase 3D Structure for P23142
Clonality
Monoclonal
Isotype
IgG2a Kappa
Host
Mouse
Purity/Purification
Protein A + Protein G affinity chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Concentration
1 mg/ml (lot specific)
Organism Species
Homo sapiens (Human)
Source
Monoclonal antibody preparation
Antibody isotype
IgG2b Kappa
Clone number
D1
Traits
Liquid
Immunogen
Recombinant FBLN1 (Leu176~Val398 (Accession # P23142)) expressed in E.coli
Preparation and Storage
Avoid repeated freeze/thaw cycles.
Store at 4ºC for frequent use.
Aliquot and store at -20ºC for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-FBLN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-FBLN1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-FBLN1 antibody
Western blotting: 0.5-2 ug/mL;1:500-2000
Immunohistochemistry: 5-20 ug/mL;1:50-200
Immunocytochemistry: 5-20 ug/mL;1:50-200

Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-FBLN1 antibody
Western Blot: Samples. Lane1: Human Serum; Lane2: Rat Placenta Tissue;
anti-FBLN1 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-FBLN1 antibody
Western Blot: Sample: Recombinant protein.
anti-FBLN1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for FBLN1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
fibulin-1 isoform C
NCBI Official Synonym Full Names
fibulin 1
NCBI Official Symbol
FBLN1  [Similar Products]
NCBI Official Synonym Symbols
FBLN; FIBL1
  [Similar Products]
NCBI Protein Information
fibulin-1
UniProt Protein Name
Fibulin-1
UniProt Gene Name
FBLN1  [Similar Products]
UniProt Synonym Gene Names
FIBL-1  [Similar Products]
NCBI Summary for FBLN1
Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]
UniProt Comments for FBLN1
FBLN1: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. A chromosomal aberration involving FBLN1 is found in a complex type of synpolydactyly referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation t(12;22)(p11.2;q13.3) with C12orf2. Fibroblasts derived from a patient with synpolydactyly displayed alterations in the level of isoform D splice variant incorporated into the ECM and secreted into the conditioned culture medium. By contrast, the expression of isoform C was not perturbed in the patients fibroblasts. Furthermore, no aberrant polypeptides were detected in extracts of cultured patients fibroblasts. The translocation t(12;22) may result in haploinsufficiency of the isoform D splice variant, which could lead to the observed limb malformation. Elevated expression and altered processing of FBLN1 protein is associated with human breast cancer. Belongs to the fibulin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: basement membrane; extracellular matrix; extracellular region; extracellular space; fibrinogen complex; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; extracellular matrix structural constituent; fibronectin binding; identical protein binding; protease activator activity; protein C-terminus binding; protein complex binding

Biological Process: embryo implantation; extracellular matrix organization; integrin-mediated signaling pathway; negative regulation of cell adhesion; negative regulation of protein phosphorylation; viral process

Disease: Synpolydactyly 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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