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anti-LGALS3 antibody :: Mouse Galectin3 Monoclonal Antibody

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Catalog # MBS533328
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anti-LGALS3 antibody
Product Name

Galectin3 (LGALS3), Monoclonal Antibody

Popular Item
Full Product Name

Galectin3 antibody

Product Synonym Names
Monoclonal Galectin 3; Anti-Galectin 3; Galectin -3; CPB-35; IgE-binding; L-29; MAC2; Galectin 3; Galectin-3
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
153619
3D Structure
ModBase 3D Structure for P17931
Clonality
Monoclonal
Isotype
IgG1
Clone Number
38B2
Host
Mouse
Species Reactivity
To be determined by end-user.
Purity/Purification
Galectin 3 antibody was affinity purified with protein A
Form/Format
Lyophilized product from 1% BSA in PBS, pH 7.4 containing 0.05% NaN3, reconstitute with 1 ml of distilled water
Concentration
100ug lyophilized (lot specific)
Source Note
Supernatant
Biological Significance
Galectin is widely distributed in nematodes, insects, and porifers, as well as vertebrates, and it has also been found to be present in true fungi. Galectin does not just occur in the cytoplasm, it is also present in the nucleus, on the cell surface, in the extracellular matrix, etc., and it is thought to be involved in many biological phenomena, including development, differentiation, morphogenesis, tumor metastasis, cell death, and RNA splicing. Galectin3 is a beta galactoside-binding protein that has been named IgE-binding protein, CBP35, CBP30, Mac2, L29, L31, L34, etc., and structurally it is a chimera-type lectin composed of a sugarchain-binding domain (galectin domain) and a nonlectin domain. Its biological function is still uncertain, but many studies that should elucidate its function have been performed, and as a result participation of galectin-3 has been demonstrated in the biological phenomena of cell growth, adhesion, metastasis, and apoptosis. For example, a positive correlation has been shown between galectin-3 expression and the degree of malignant transformation in certain types of cell lines. A positive correlation has also recently been shown between galectin-3 expression and degree of malignancy in certain types of malignant tumors, and measurement of galectin3 is expected to possibly serve as an index of degree of tumor malignancy.
Immunogen
Galectin 3 antibody was raised in mouse using recombinant galectin3 protein as the immunogen
Preparation and Storage
Store lyophilized product at 4 degree C up to 5 years and solution at -20 degree C up to 2 years.
Other Notes
Small volumes of anti-LGALS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LGALS3 antibody
Human Galectin 3 antibody
Product Categories/Family for anti-LGALS3 antibody
Applications Tested/Suitable for anti-LGALS3 antibody
Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-LGALS3 antibody
IHC: 25 ug/mL
WB: 25 ug/ml
NCBI/Uniprot data below describe general gene information for LGALS3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,152 Da[Similar Products]
NCBI Official Full Name
galectin-3
NCBI Official Synonym Full Names
lectin, galactoside-binding, soluble, 3
NCBI Official Symbol
LGALS3  [Similar Products]
NCBI Official Synonym Symbols
L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2
  [Similar Products]
NCBI Protein Information
galectin-3
UniProt Protein Name
Galectin-3
UniProt Synonym Protein Names
35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen
UniProt Gene Name
LGALS3  [Similar Products]
UniProt Synonym Gene Names
MAC2; Gal-3; CBP 35; GALBP  [Similar Products]
UniProt Entry Name
LEG3_HUMAN
NCBI Summary for LGALS3
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]
UniProt Comments for LGALS3
Galectin-3: galactose-specific lectin which binds IgE. Expressed at a high level in the colonic epithelium. Also abundant in activated macrophages.

Protein type: Extracellular matrix; Cell surface; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q22.3

Cellular Component: extracellular matrix; spliceosome; extracellular space; proteinaceous extracellular matrix; membrane; cytoplasm; mitochondrial inner membrane; plasma membrane; immunological synapse; nucleus; external side of plasma membrane

Molecular Function: protein binding; laminin binding; IgE binding; carbohydrate binding; chemoattractant activity

Biological Process: neutrophil chemotaxis; extracellular matrix organization and biogenesis; RNA splicing; negative regulation of endocytosis; regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; macrophage chemotaxis; monocyte chemotaxis; positive chemotaxis; epithelial cell differentiation; eosinophil chemotaxis; innate immune response; mRNA processing; skeletal development
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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