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anti-GHR antibody :: Growth hormone receptor Monoclonal Antibody

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Catalog # MBS660032
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anti-GHR antibody
Product Name

Growth hormone receptor (GHR), Monoclonal Antibody

Full Product Name

Monoclonal mouse anti-human growth hormone receptor

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 604271
Clonality
Monoclonal
Isotype
IgG1 for MAbs GhRG7, GhRD5 and GhRG6
Clone Number
GhRG7, GhRD5, GhRG6
Specificity
Both GhR-hormone complex and free GhR.
Purity/Purification
Chromatography on protein G Sepharose
Form/Format
PBS, pH 7.4, 0.1 % sodium azide (NaN3)
Clone Note
Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with human growth hormone receptor conjugated with APP.
Preparation and Storage
4 degree C
Other Notes
Small volumes of anti-GHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GHR antibody
Indirect ELISA (EIA)
NCBI/Uniprot data below describe general gene information for GHR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,237 Da[Similar Products]
NCBI Official Full Name
growth hormone receptor, partial
NCBI Official Synonym Full Names
growth hormone receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein
UniProt Protein Name
Growth hormone receptor
UniProt Synonym Protein Names
Somatotropin receptorGrowth hormone-binding protein; GH-binding protein; GHBPAlternative name(s):Serum-binding protein
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
GH receptor; GH-binding protein; GHBP  [Similar Products]
UniProt Entry Name
GHR_HUMAN
NCBI Summary for GHR
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
UniProt Comments for GHR
GH receptor: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. Defects in GHR are a cause of Laron syndrome (LARS). A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the type I cytokine receptor family. Type 1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 5p13-p12

Cellular Component: extracellular space; cell surface; integral to plasma membrane; extracellular region; plasma membrane; integral to membrane; receptor complex

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein homodimerization activity; growth factor binding; peptide hormone binding; protein kinase binding

Biological Process: succinate metabolic process; oxaloacetate metabolic process; activation of MAPK activity; positive regulation of multicellular organism growth; tyrosine phosphorylation of JAK2 protein; fatty acid metabolic process; response to estradiol stimulus; positive regulation of tyrosine phosphorylation of Stat3 protein; 2-oxoglutarate metabolic process; allantoin metabolic process; receptor internalization; creatinine metabolic process; isoleucine metabolic process; cytokine and chemokine mediated signaling pathway; citrate metabolic process; valine metabolic process; regulation of multicellular organism growth; endocytosis; JAK-STAT cascade; creatine metabolic process; multicellular organismal metabolic process; cellular response to hormone stimulus; positive regulation of peptidyl-tyrosine phosphorylation; insulin-like growth factor receptor signaling pathway; positive regulation of tyrosine phosphorylation of Stat5 protein; response to cycloheximide; taurine metabolic process

Disease: Hypercholesterolemia, Familial; Laron Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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