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anti-IGF1R antibody :: Mouse IGF-1 receptor Monoclonal Antibody

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Catalog # MBS190274
Unit / Price
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  0.1 mg  /  $320 +1 FREE 8GB USB
anti-IGF1R antibody
Product Name

IGF-1 receptor (IGF1R), Monoclonal Antibody

Full Product Name

IGF-1 Receptor Monoclonal Antibody

Product Synonym Names
Anti-IGF-1 receptor; IGF-1 Receptor
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_010443.3 (143851692..144145063, complement). Location: 1q17-q21; 1
3D Structure
ModBase 3D Structure for Q29000
Clonality
Monoclonal
Isotype
IgG1
Host
Mouse
Specificity
Anti-IGF-1 receptor [Murine MAb recognizes human IGF-1 receptor; stimulates binding of IGF-1 and 2, stimulates cell growth.]
All three clones are specific for the human IGF-1 receptor
This product (3B7) stimulates binding of IGF-1 and -2; stimulates basal and IGF- 1 stimulated cell growth.
Form/Format
100 ug Protein G-purified antibody in PBS, pH 7.4
Antigen
Purified human placental IGF-1 receptors.
Stabilizer
None
Preservatives
None. Available on request.
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles
Other Notes
Small volumes of anti-IGF1R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IGF1R antibody
Immunoblot, Immunoprecipitation
Application Notes for anti-IGF1R antibody
Use these antibodies in research studies to delineate signal transduction pathways specific for IGF's and for detecting IGF-1 receptors in crude samples. 35101 may be used to immunoprecipitate IGF-1 receptors. 35102 and 35103 can recognize the IGF-1 alpha subunit on immunoblots.
NCBI/Uniprot data below describe general gene information for IGF1R. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,615 Da[Similar Products]
NCBI Official Full Name
insulin-like growth factor 1 receptor
NCBI Official Symbol
IGF1R  [Similar Products]
NCBI Official Synonym Symbols
IGF1R
  [Similar Products]
NCBI Protein Information
insulin-like growth factor 1 receptor; IGF-1 receptor; IGF-I receptor; insulin-like growth factor I receptor; insulin-like growth factor receptor 1; insulin-like growth factor-I receptor; insulin-like growth factor 1 receptor beta subunit
UniProt Protein Name
Insulin-like growth factor 1 receptor
UniProt Synonym Protein Names
Insulin-like growth factor I receptor
UniProt Gene Name
IGF1R  [Similar Products]
UniProt Entry Name
IGF1R_PIG
UniProt Comments for IGF1R
Function: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Cofactor: Manganese

Subunit structure: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with GNB2L1/RACK1

Subcellular location: Membrane; Single-pass type I membrane protein.

Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 1 fibronectin type-III domain.Contains 1 protein kinase domain.
Product References and Citations for anti-IGF1R antibody
Xiong et al. (1992) Proc Natl Acad Sci USA 89: 5356; Li et al. (1993) Biochem Biophys Res Commun 196: 92.

Research Articles on IGF1R
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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