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anti-IL1R2 antibody :: Mouse Interleukin 1 Receptor Type II Monoclonal Antibody

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Catalog # MBS604859
Unit / Price
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  0.1 mg  /  $690 +1 FREE 8GB USB
anti-IL1R2 antibody
Product Name

Interleukin 1 Receptor Type II (IL1R2), Monoclonal Antibody

Popular Item
Full Product Name

Interleukin 1 Receptor Type II (IL-1RII)

Product Synonym Names
Anti -Interleukin 1 Receptor Type II (IL-1RII)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (102608306..102644885). Location: 2q12
OMIM
147811
3D Structure
ModBase 3D Structure for P27930
Clonality
Monoclonal
Isotype
IgG1
Clone Number
6A574
Host
Mouse
Specificity
Recognizes human Interleukin 1 Receptor Type II.
Purity/Purification
Affinity purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
Concentration
0.1 mg/mL (lot specific)
Preparation and Storage
May be stored at 4°C for short term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-IL1R2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IL1R2 antibody
The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. The IL-1 R II is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1 R I. The decoy IL-1 R II can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1 R II exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts.
Product Categories/Family for anti-IL1R2 antibody
Applications Tested/Suitable for anti-IL1R2 antibody
Suitable for use in Western Blot, Flow Cytometry and Immunoassays. Other applications have not been tested.
Application Notes for anti-IL1R2 antibody
Flow Cytometry: 1:50
Western Blot: 1:50
Immunoassays: 1:50

Optimal dilutions to be determined by the researcher.
NCBI/Uniprot data below describe general gene information for IL1R2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
interleukin-1 receptor type 2
NCBI Official Synonym Full Names
interleukin 1 receptor, type II
NCBI Official Symbol
IL1R2  [Similar Products]
NCBI Official Synonym Symbols
IL1RB; CD121b; MGC47725
  [Similar Products]
NCBI Protein Information
interleukin-1 receptor type 2; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2; IL-1R-beta; antigen CDw121b; OTTHUMP00000161283; OTTHUMP00000207968; OTTHUMP00000207969; interleukin-1 receptor beta; interleukin-1 receptor type II; CD121 antigen-like family member B; type II interleukin-1 receptor, beta
UniProt Protein Name
Interleukin-1 receptor type 2
UniProt Synonym Protein Names
CD121 antigen-like family member B; CDw121b; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor type II
Protein Family
UniProt Gene Name
IL1R2  [Similar Products]
UniProt Synonym Gene Names
IL1RB  [Similar Products]
UniProt Entry Name
IL1R2_HUMAN
NCBI Summary for IL1R2
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq]
UniProt Comments for IL1R2
IL-1RB: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Belongs to the interleukin-1 receptor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: extracellular region; integral to membrane; plasma membrane

Molecular Function: protein binding; interleukin-1, Type II, blocking receptor activity; interleukin-1 receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway; immune response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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