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anti-JAGGED2 antibody :: Hamster JAGGED2 Monoclonal Antibody

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Catalog # MBS219866
Unit / Price
  0.1 mg  /  $210 +1 FREE 8GB USB
Product Name

JAGGED2, Monoclonal Antibody

Also Known As

HAMSTER ANTI MOUSE JAGGED2

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1238
OMIM
602570
Clonality
Monoclonal
Isotype
IgG
Clone Number
HMJ2-1
Host
Hamster
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Preparation
Immunogen
Jagged2-expressing CHO cells.
Histology Positive Control Tissue
Target Species
Mouse
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-JAGGED2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-JAGGED2 antibody
Hamster anti Mouse JAGGED2 antibody, clone HMJ2-1 specifically recognizes Jagged2, one of the five major ligands of the Notch signaling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signaling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell hematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta-like protein 1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and the gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signaling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. Jagged2 is expressed by stromal and thymic lymphoid cells, and by splenic macrophages and dendritic cells (DCs), and plays a vital role during limb, craniofacial, tooth, and thymic development, as well as being implicated in the maintenance and function of neuronal cells in both the central (CNS) and enteric (gastrointestinal) nervous system. Studies have shown that the anti-tumor cytolytic activity of natural killer (NK) cells can be enhanced by Jagged2 stimulation, and that the vital role which DC Jagged2 expression plays in DC-mediated NK cell activation, may
Applications Tested/Suitable for anti-JAGGED2 antibody
Immunohistology Frozen, Flow cytometry (FC/FACS)
Application Notes for anti-JAGGED2 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.

Testing Data of anti-JAGGED2 antibody
Paraffin embedded human testis stained with Hamster anti Mouse Jagged 2 (MBS219865) followed by Goat anti Hamster IgG:HRP (MBS235197)
anti-JAGGED2 antibody Testing Data image
Testing Data of anti-JAGGED2 antibody
Mouse Jagged 2 transfected cells stained with Hamster anti Mouse Jagged 2 (MBS219865)
anti-JAGGED2 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for JAGGED2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
129,235 Da
NCBI Official Full Name
protein jagged-2 isoform a
NCBI Official Synonym Full Names
jagged 2
NCBI Official Symbol
NCBI Official Synonym Symbols
HJ2; SER2
  [Similar Products]
NCBI Protein Information
protein jagged-2
UniProt Protein Name
Protein jagged-2
UniProt Gene Name
UniProt Synonym Gene Names
Jagged2; hJ2  [Similar Products]
UniProt Entry Name
JAG2_HUMAN
NCBI Summary for JAGGED2
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for JAGGED2
JAG2: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development. Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; growth factor activity; calcium ion binding; Notch binding

Biological Process: regulation of cell adhesion; thymic T cell selection; Notch signaling pathway; in utero embryonic development; Notch receptor processing; cell cycle; regulation of cell migration; odontogenesis of dentine-containing teeth; regulation of cell proliferation; respiratory system process; morphogenesis of embryonic epithelium; spermatogenesis; auditory receptor cell fate commitment; cell differentiation; skeletal development; T cell differentiation; gamma-delta T cell differentiation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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