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anti-LOXL1 antibody :: Mouse Lysyl Oxidase Like Protein 1 (LOXL1) Monoclonal Antibody

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Catalog # MBS2012763 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
Scan QR to view Datasheet
  0.01 mg  /  $105 +1 FREE 8GB USB
  0.02 mg  /  $110 +1 FREE 8GB USB
  0.05 mg  /  $145 +1 FREE 8GB USB
  0.1 mg  /  $185 +1 FREE 8GB USB
  0.2 mg  /  $235 +1 FREE 8GB USB
  1 mg  /  $540 +1 FREE 8GB USB
Product Name

Lysyl Oxidase Like Protein 1 (LOXL1), Monoclonal Antibody

Popular Item
Full Product Name

Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS2012763 Technical Datasheet
Chromosome Location
Chromosome: 15; NC_000015.9 (74218789..74244478). Location: 15q22
OMIM
153456
3D Structure
ModBase 3D Structure for Q08397
Clonality
Monoclonal
Isotype
IgG2a Kappa
Clone Number
C1
Host
Mouse
Purity/Purification
Protein A + Protein G affinity chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Concentration
0.57 mg/ml (lot specific)
Organism Species
Homo sapiens (Human)
Source
Monoclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant LOXL1 (Leu369~Ser574) expressed in E.coli
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 4ºC for frequent use.
Aliquot and store at -20ºC for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-LOXL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-LOXL1 antibody
Western Blot(WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP).
Application Notes for anti-LOXL1 antibody
Western blotting: 0.5-2 ug/mL;1:280-1100
Immunohistochemistry: 5-20 ug/mL;1:28-110
Immunocytochemistry: 5-20 ug/mL;1:28-110

Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-LOXL1 antibody
Western Blot: Sample: Recombinant LOXL1, Human.
anti-LOXL1 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-LOXL1 antibody
Western Blot; Sample: Lane 1 Porcine Cerebrum lysate; Lane 2: Rat Cerebrum lysate; Primary Ab: 2 ug/ml Mouse Anti-Human LOXL1 Antibody
anti-LOXL1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for LOXL1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
lysyl oxidase homolog 1 preproprotein
NCBI Official Synonym Full Names
lysyl oxidase-like 1
NCBI Official Symbol
LOXL1  [Similar Products]
NCBI Official Synonym Symbols
LOL; LOXL
  [Similar Products]
NCBI Protein Information
lysyl oxidase homolog 1; lysyl oxidase-like protein 1
UniProt Protein Name
Lysyl oxidase homolog 1
UniProt Synonym Protein Names
Lysyl oxidase-like protein 1
Protein Family
UniProt Gene Name
LOXL1  [Similar Products]
UniProt Synonym Gene Names
LOXL; LOL  [Similar Products]
UniProt Entry Name
LOXL1_HUMAN
NCBI Summary for LOXL1
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
UniProt Comments for LOXL1
LOXL1: Active on elastin and collagen substrates. Genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome (XFS); also called exfoliation glaucoma (XFG). XFS is a disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations. Belongs to the lysyl oxidase family.

Protein type: Secreted, signal peptide; Secreted; Extracellular matrix; Oxidoreductase; EC 1.4.3.-

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: extracellular matrix; extracellular space; acrosome; extracellular region; basement membrane

Molecular Function: copper ion binding; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Biological Process: extracellular matrix organization and biogenesis; response to lipopolysaccharide; protein amino acid deamination

Disease: Exfoliation Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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