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anti-MHC Class II antibody :: Mouse MHC Class II Monoclonal Antibody

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Catalog # MBS140118
Unit / Price
  0.5 mg  /  $305 +1 FREE 8GB USB
  1 mg  /  $455 +1 FREE 8GB USB
anti-MHC Class II antibody
Product Name

MHC Class II, Monoclonal Antibody

Full Product Name

Mouse Anti MHC Class II (I-A) FITC

Product Synonym Names
MHC Class II, I-A Antibody, FITC; MHC Class II, (I-A) Mouse Antibody, FITC; MHC Class II FITC
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
NYRmI-A
Host
Mouse
Specificity
Recognizes most MHC class II haplotypes (b,f,p,q,r,s,u,v), but weak against I-Ak.
Purity/Purification
Ion exchange column.
Concentration
1mg/ml in PBS (after reconstitution). (lot specific)
Reconstitution
Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Immunogen
Purified mouse LN B cells (C3H anti-C57Bl6).
Antibody Properties
Cytotoxic and staining antibody. For staining, use 10ml/1,000,000 cells. Titer for cytotoxicity should be determined by the investigator.
Available Conjugates
This antibody is also available unconjugated and conjugated to Biotin.
Preparation and Storage
Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
Other Notes
Small volumes of anti-MHC Class II antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MHC Class II antibody
Introduction: MHC Class II is consists of 2 membrane spanning proteins. Each of these proteins is roughly 30 kDa, and has of two Globular domains, Alpha-1, Alpha-2, Beta-1 and Beta-2. The two regions farthest away from the membrane are alpha-1 and beta-1. The two proteins link without Covalent Bonds. The MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a third protein called the "invariant chain," is necessary for stabilizing the complex, without it, they will not associate. The MHC-invariant complex is then passed from the RER, into and out of, the Golgi body. It fuses with an Endocytic compartment, where an external protein has been sampled and degraded.
NCBI/Uniprot data below describe general gene information for MHC Class II. It may not necessarily be applicable to this product.
NCBI GI #
NCBI Accession #
Molecular Weight
26,489 Da
NCBI Official Full Name
MHC class II HLA-DQ-beta-1
UniProt Protein Name
MHC class II HLA-DQ-beta-1
UniProt Synonym Protein Names
MHC class II HLA-DQ-beta-1
UniProt Gene Name
HLA-DQB1  [Similar Products]
UniProt Entry Name
O19707_HUMAN
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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