AAH17568.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Neuregulin 4
NCBI Official Synonym Full Names
neuregulin 4
NCBI Official Synonym Symbols
NCBI Protein Information
pro-neuregulin-4, membrane-bound isoform
UniProt Protein Name
Pro-neuregulin-4, membrane-bound isoform
UniProt Synonym Gene Names
NCBI Summary for NRG4
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
UniProt Comments for NRG4
NRG4: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Belongs to the neuregulin family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q24.2
Cellular Component: extracellular region; extracellular space
Molecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding
Biological Process: MAPKKK cascade; organ development; phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade
Research Articles on NRG4
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Products associated with anti-NRG4 antibody
Pathways associated with anti-NRG4 antibody
Diseases associated with anti-NRG4 antibody
Organs/Tissues associated with anti-NRG4 antibody
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