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anti-BGLAP antibody :: Mouse OSTEOCALCIN Monoclonal Antibody

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Catalog # MBS211439
Unit / Price
  0.2 mg  /  $440 +1 FREE 8GB USB
anti-BGLAP antibody
Product Name

OSTEOCALCIN (BGLAP), Monoclonal Antibody

Popular Item
Also Known As

MOUSE ANTI HUMAN OSTEOCALCIN

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
100
OMIM
112260
3D Structure
ModBase 3D Structure for P02818
Clonality
Monoclonal
Isotype
IgG1
Clone Number
6F9G4E10
Host
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
Approximate Protein Concentration: 1.0 mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Preparation
Buffer Solution
Phosphate buffered saline
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-BGLAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forBGLAPpurchase
MOUSE ANTI HUMAN OSTEOCALCIN:

This antibody is mouse derived against human osteocalcin (anti osteocalcin antibody or mouse anti osteocalcin)
Osteocalcin (bone gamma-carboxyglutamic acid-containing protein or BGLAP), is a protein found in bone and dentin. It is encoded by the BGLAP gene and its effects are transduced by the GPRC6A receptor. It is often used as biochemical marker for bone formation
Osteoblasts secrete osteocalcin and it plays a role in the body's metabolic regulation such as pro-osteoblast stimulation and bone building. Osteocalcin acts on Leydig cells (via the GPRC6A receptor) of the testis to stimulate testosterone biosynthesis and therefore affect male fertility. Osteocalcin has also been implicated in bone mineralization and calcium ion homeostasis. It acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which causes an increase in the sensitivity to insulin.
Cross species reactivity for this antibody has been demonstrated to mouse, rat and human sequences. Applications of this recombinant protein tool include western blotting, ELISA IHC, protein/ tissue expression, gene expression and a multitude of other research applications.
Related Product Information for
anti-BGLAP antibody
Mouse anti Human Osteocalcin antibody, clone 6F9G4E10 recognizes intact human osteocalcin in a 2 site assay and reacts with osteocalcin fragments corresponding to amino acids 1-19, 7-19 and 15-31 of the native molecule. It does not recognize fragments representing amino acids 20-42 or intact bovine osteocalcin.Osteocalcin (Bone Gla Protein) is a 49 amino acid single chain vitamin K dependent protein (MW 5.8 kDa), made by osteoblasts that is a major component of the non-collagenous bone matrix. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Paget's disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency.
Applications Tested/Suitable for anti-BGLAP antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for BGLAP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,963 Da[Similar Products]
NCBI Official Full Name
osteocalcin preproprotein
NCBI Official Synonym Full Names
bone gamma-carboxyglutamate (gla) protein
NCBI Official Symbol
BGLAP  [Similar Products]
NCBI Official Synonym Symbols
OC; BGP; OCN
  [Similar Products]
NCBI Protein Information
osteocalcin; bone Gla protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); gamma-carboxyglutamic acid-containing protein
UniProt Protein Name
Osteocalcin
UniProt Synonym Protein Names
Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein
Protein Family
UniProt Gene Name
BGLAP  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
OSTCN_HUMAN
NCBI Summary for BGLAP
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
UniProt Comments for BGLAP
osteocalcin: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Belongs to the osteocalcin/matrix Gla protein family.

Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: Golgi apparatus; extracellular space; rough endoplasmic reticulum; cytoplasm; dendrite; perikaryon

Molecular Function: structural constituent of bone; hydroxyapatite binding; calcium ion binding; structural molecule activity

Biological Process: response to drug; response to gravity; regulation of bone resorption; response to glucocorticoid stimulus; cell aging; response to testosterone stimulus; bone mineralization; osteoblast development; odontogenesis; osteoblast differentiation; response to ethanol; response to vitamin D; regulation of osteoclast differentiation; response to vitamin K; response to estrogen stimulus; response to zinc ion; response to mechanical stimulus; response to hydroxyisoflavone; response to activity; cell adhesion; regulation of bone mineralization; skeletal development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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