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anti-E7 antibody :: Mouse PAPILLOMAVIRUS 11 PROTEIN E7 Monoclonal Antibody

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Catalog # MBS216323
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anti-E7 antibody
Product Name

PAPILLOMAVIRUS 11 PROTEIN E7, Monoclonal Antibody

Popular Item
Full Product Name

MOUSE ANTI HUMAN PAPILLOMAVIRUS 11 PROTEIN E7

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P04020
Clonality
Monoclonal
Isotype
IgG1
Clone Number
711-66
Host
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium azide
Preparation
Immunogen
Protein E7 from human papillomavirus 11.
Fusion Partners
Target Species
Viral
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-E7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-E7 antibody
Mouse anti Human Papillomavirus 11 Protein E7 antibody, clone 711-66 recognizes the E7 protein of human papilloma virus 11. Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Type 11 HPV is a low risk type that causes anogenital warts and is not linked with cervical cancer. In rare cases HPV-11 may cause respiratory papillomatosis, where warts form on the larynx or other areas of the respiratory tract. The viral protein E7 binds to Rb (retinoblastoma protein) and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. This binding is of much lower affinity than the high-risk HPV E7 proteins. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection. Mouse anti Human Papillomavirus 11 Protein E7 antibody, clone 711-66 cross-reacts minimally with the E7 protein of HPV-16 and HPV-18.
Applications Tested/Suitable for anti-E7 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for E7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI Accession #
UniProt Primary Accession #
Molecular Weight
10,889 Da[Similar Products]
NCBI Official Full Name
Protein E7
UniProt Protein Name
Protein E7
UniProt Gene Name
UniProt Entry Name
VE7_HPV11
UniProt Comments for E7
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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