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anti-KLK3 antibody :: Mouse Prostate Specific Antigen (PSA) Total Monoclonal Antibody

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Catalog # MBS311572
Unit / Price
  1 mg  /  $355 +1 FREE 8GB USB
anti-KLK3 antibody
Product Name

Prostate Specific Antigen (PSA) Total (KLK3), Monoclonal Antibody

Popular Item
Full Product Name

MAb to PSA, Total

Product Synonym Names
Monoclonal Antibody to Prostate Specific Antigen (PSA), Total
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.9 (51358171..51364020). Location: 19q13.41
OMIM
176820
3D Structure
ModBase 3D Structure for P07288
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
5A6
Host
Mouse
Specificity
Specific for total PSA in equimolar determination, epitope 5. No cross-reactivity with human kallikrein 2.
Purity/Purification
>90% pure (SDS-PAGE). Protein A chromatography
Form/Format
Purified, Liquid
Concentration
6.5 mg/ml (OD280nm, E0.1% = 1.4) (lot specific)
Source
Ascites
Immunogen
Human PSA antigen purified from seminal plasma
Buffer
PBS, pH 7.4
Preservative
0.9% Sodium azide
Important Note
Centrifuge before opening to ensure complete recovery of vial contents.
Warnings
This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Preparation and Storage
Store at 2 to 8 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-KLK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KLK3 antibody
EIA/ELISA, Lateral Flow

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Application Notes for anti-KLK3 antibody
Detection of total PSA:
Capture : Detection
MBS311575 : MBS311572
MBS312603 : MBS311572
MBS312864 : MBS311572
MBS312739 : MBS311572
MBS312890 : MBS311572

Detection of free PSA:
Capture Detection
MBS311577 : MBS311572
MBS311572 : MBS311577

Suitable for use in ELSIA and lateral flow. Each laboratory should determine an optimum working titer for use in its particualr application. Other applications have not been tested but use in such assays should not be nesscessarly be excluded.
NCBI/Uniprot data below describe general gene information for KLK3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
prostate-specific antigen isoform 1 preproprotein
NCBI Official Synonym Full Names
kallikrein-related peptidase 3
NCBI Official Symbol
NCBI Official Synonym Symbols
APS; PSA; hK3; KLK2A1
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NCBI Protein Information
prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen
UniProt Protein Name
Prostate-specific antigen
UniProt Synonym Protein Names
Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
KLK3_HUMAN
NCBI Summary for KLK3
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq]
UniProt Comments for KLK3
Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Catalytic activity: Preferential cleavage: -Tyr-|-Xaa-.

Enzyme regulation: Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Ref.18

Subcellular location: Secreted.

Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.

Sequence caution: The sequence AAD14185.1 differs from that shown. Reason: Erroneous initiation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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