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anti-REN antibody :: Mouse Renin Monoclonal Antibody

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Catalog # MBS838098
Unit / Price
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  0.25 mg  /  $410 +1 FREE 8GB USB
anti-REN antibody
Product Name

Renin, Monoclonal Antibody

Popular Item
Full Product Name

Renin antibody

Product Synonym Names
Monoclonal Renin; Anti-Renin; FLJ10761; HNFJ2; REN; RENI; Renin; renin precursor renal; angiotensin-forming enzyme; Angiotensinogenase
Product Gene Name
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
179820
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
M83161
Host
Mouse
Species Reactivity
100% for active renin, <4% for Prorenin
Specificity
Recognizes human Renin and Prorenin
Purity/Purification
Renin antibody was purified by urified by Protein A affinity chromatography
Form/Format
Purified unconjugated liquid in 0.1M BBS, pH 8.0, with no preservative
Concentration
2.8 mg/ml (lot specific)
Immunogen
Human Recombinant renin
Preparation and Storage
Store at 4°C
Other Notes
Small volumes of anti-REN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-REN antibody
Renin is an enzyme that participates in the body's renin-angiotensin system (RAS)-also known as the renin-angiotensin-aldosterone axis-that mediates extracellular volume (i.e., that the blood plasma, lymph and interstitial fluid), and arterial vasocontriction. Thus, it regulates the body's mean arterial blood pressure.
Product Categories/Family for anti-REN antibody
Applications Tested/Suitable for anti-REN antibody
ELISA (EIA), Radioimmunoassay (RIA), Lateral Flow
Application Notes for anti-REN antibody
MBS838098 can be used as the capture antibody in a matched pair immunoassay inconjunction with MBS838113 as the detection antibody
NCBI/Uniprot data below describe general gene information for REN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
renin preproprotein
NCBI Official Synonym Full Names
renin
NCBI Official Symbol
NCBI Official Synonym Symbols
HNFJ2
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NCBI Protein Information
renin
UniProt Protein Name
Renin
UniProt Synonym Protein Names
Angiotensinogenase
Protein Family
UniProt Gene Name
UniProt Entry Name
RENI_HUMAN
NCBI Summary for REN
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
UniProt Comments for REN
REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; EC 3.4.23.15; Secreted; Protease

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space; cytoplasm; plasma membrane; extracellular region

Molecular Function: peptidase activity; insulin-like growth factor receptor binding; aspartic-type endopeptidase activity; receptor binding

Biological Process: response to cAMP; hormone-mediated signaling; male gonad development; renin-angiotensin regulation of aldosterone production; drinking behavior; cell maturation; response to lipopolysaccharide; proteolysis; angiotensin maturation; cellular protein metabolic process; regulation of MAPKKK cascade; regulation of blood pressure; beta-amyloid metabolic process; mesonephros development; kidney development

Disease: Renal Tubular Dysgenesis; Hyperuricemic Nephropathy, Familial Juvenile, 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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