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anti-SERPINA7 antibody :: Thyroxine Binding Globulin (TBG) Monoclonal Antibody

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Catalog # MBS311702
Unit / Price
  1 mg  /  $360 +1 FREE 8GB USB
anti-SERPINA7 antibody
Product Name

Thyroxine Binding Globulin (TBG) (SERPINA7), Monoclonal Antibody

Also Known As

MAb to TBG

Product Synonym Names
Monoclonal Antibody to Thyroxine Binding Globulin (TBG)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: X; NC_000023.10 (105277190..105282718, complement). Location: Xq22.2
OMIM
314200
3D Structure
ModBase 3D Structure for P05543
Clonality
Monoclonal
Isotype
IgG2a, kappa
Clone Number
027-10439
Host
Host: Mouse
Source: Ascites
Specificity
Thyroxine Binding Globulin (TBG)
Thyroxine Binding Globulin (TBG)
Purity/Purification
>90% pure (SDS-PAGE). Protein A chromatography.
Product is sterile filtered.
Form/Format
Purified, Liquid
Concentration
5.1mg/ml (OD280nm, E^0.1% = 1.4) (lot specific)
Affinity Constant
1 x 10^9
Buffer
10mM Phosphate, pH 7.4 containing 150mM Sodium chloride
Preservative
None. OPEN ASEPTICALLY!
Preparation and Storage
Short term (up to 7 days) store at 2 to 8 degree C. Long term, aliquot and store at <-40 degree C. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used. Avoid repeated freeze/th
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-SERPINA7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SERPINA7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,325 Da[Similar Products]
NCBI Official Full Name
thyroxine-binding globulin
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
NCBI Official Symbol
SERPINA7  [Similar Products]
NCBI Official Synonym Symbols
TBG; FLJ17820
  [Similar Products]
NCBI Protein Information
thyroxine-binding globulin; serpin A7; OTTHUMP00000023778; OTTHUMP00000023779; T4-binding globulin; thyroxin-binding globulin; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
UniProt Protein Name
Thyroxine-binding globulin
UniProt Synonym Protein Names
Serpin A7; T4-binding globulin
UniProt Gene Name
SERPINA7  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
THBG_HUMAN
NCBI Summary for SERPINA7
There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3 -triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.
UniProt Comments for SERPINA7
Function: Major thyroid hormone transport protein in serum.

Subcellular location: Secreted.

Tissue specificity: Expressed by the liver and secreted in plasma.

Polymorphism: Two qualitative TBG variants occur in particular populations. TBG-A is found in 40% of Australian aborigines, it has reduced affinity for thyroxine and triiodothyroxine and increased susceptibility to inactivation by heat or acid. TBG-S ('s' for slow shift on isoelectic focusing) is found in blacks, Eskimos, Melanesians, Polynesians and Indonesians, but not in Caucasians; TBG-S is slightly more thermolabile.

Involvement in disease: Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [

MIM:314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid.

Sequence similarities: Belongs to the serpin family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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