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anti-TIMP3 antibody :: Mouse TIMP3 Monoclonal Antibody

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Catalog # MBS531921
Unit / Price
  0.1 mg  /  $650 +1 FREE 8GB USB
anti-TIMP3 antibody
Product Name

TIMP3, Monoclonal Antibody

Also Known As

TIMP3 antibody

Product Synonym Names
Monoclonal TIMP3; Anti-TIMP3; TIMP 3; TIMP-3; TIMP3
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
211
OMIM
136900
3D Structure
ModBase 3D Structure for P35625
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
136-13H4
Host
Mouse
Specificity
Human
Form/Format
Lyophilized from a volatile buffer with 100 ug of BSA. Reconstitute antibody with sterile PBS, pH7.4 or Sterile 20 mM Tris-saline pH 7.4 to a final concentration of 100 ug/ml.
Biological Significance
Metalloproteinase inhibitor 3 is an enzyme that in humans is encoded by the TIMP3 gene. This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM).
Immunogen
TIMP3 antibody was raised in mouse using a sythetic peptide corresponding to amino acid residues 170-188 of human TIMP-3 as the immunogen.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
Other Notes
Small volumes of anti-TIMP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TIMP3 antibody
Mouse monoclonal TIMP3 antibody
Applications Tested/Suitable for anti-TIMP3 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for TIMP3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,145 Da
NCBI Official Full Name
TIMP-3
NCBI Official Synonym Full Names
TIMP metallopeptidase inhibitor 3
NCBI Official Symbol
TIMP3  [Similar Products]
NCBI Official Synonym Symbols
SFD; K222; K222TA2; HSMRK222
  [Similar Products]
NCBI Protein Information
metalloproteinase inhibitor 3
UniProt Protein Name
Metalloproteinase inhibitor 3
UniProt Synonym Protein Names
Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3
UniProt Gene Name
TIMP3  [Similar Products]
UniProt Synonym Gene Names
TIMP-3  [Similar Products]
UniProt Entry Name
TIMP3_HUMAN
NCBI Summary for TIMP3
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]
UniProt Comments for TIMP3
TIMP3: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Interacts with EFEMP1. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; basement membrane; nucleus

Molecular Function: metalloendopeptidase inhibitor activity; protein binding; protease binding; metal ion binding

Biological Process: negative regulation of metalloenzyme activity; visual perception; response to cytokine stimulus; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis

Disease: Fundus Dystrophy, Pseudoinflammatory, Of Sorsby
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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