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anti-TPH antibody :: Mouse TPH Monoclonal Antibody

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Catalog # MBS533532
Unit / Price
  1 mg  /  $255 +1 FREE 8GB USB
anti-TPH antibody
Product Name

TPH, Monoclonal Antibody

Also Known As

TPH antibody (FITC)

Product Synonym Names
Monoclonal TPH; Anti-TPH; Anti TPH; TPH; Anti Total Petroleum Hydrocarbons; Total Petroleum Hydrocarbons
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
Clone Number
F12 3C8
Supplied as a 0.2um filtered liquid in 20mM NaPO4, pH 7.2, with 150mM NaCl.
2.1 mg/ml (lot specific)
Biological Significance
Tryptophan hydroxylase (TPH) is an enzyme (EC involved in the synthesis of the neurotransmitter serotonin. TPH catalyzes the following chemical reaction: L-tryptophan + tetrahydrobiopterin + O2 5-Hydroxytryptophan + 4a-hydroxytetrahydrobiopterin. It employs one cofactor, iron.
TPH antibody (FITC) was raised in mouse using TPH as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-TPH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TPH antibody
TPH antibody (FITC)
Applications Tested/Suitable for anti-TPH antibody
User optimized
NCBI/Uniprot data below describe general gene information for TPH. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Secondary Accession #
Molecular Weight
53,394 Da
NCBI Official Full Name
tryptophan hydroxylase
UniProt Protein Name
Tryptophan 5-hydroxylase 1
UniProt Synonym Protein Names
Tryptophan 5-monooxygenase 1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
TPH; TPRH; TRPH  [Similar Products]
UniProt Entry Name
UniProt Comments for TPH
TPH1: an enzyme that is rate-limiting in the biosynthesis of serotonin. It catalyzes the biopterin dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Its expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. Two alternatively spliced isoforms have been described.

Protein type: Oxidoreductase; Amino Acid Metabolism - tryptophan; EC

Chromosomal Location of Human Ortholog: 11p15.3-p14

Cellular Component: neuron projection; cytosol

Molecular Function: amino acid binding; tryptophan 5-monooxygenase activity; iron ion binding

Biological Process: circadian rhythm; indolalkylamine biosynthetic process; aromatic amino acid family metabolic process; negative regulation of ossification; positive regulation of fat cell differentiation; bone remodeling; serotonin biosynthetic process
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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