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Mouse V alpha 24 J alpha 18 TCR Monoclonal Antibody

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Catalog # MBS832325
Unit / Price
  25 Tests  /  $290 +1 FREE 8GB USB
  100 Tests  /  $615 +1 FREE 8GB USB
Flow Cytometry (FC/FACS)
Product Name

V alpha 24 J alpha 18 TCR, Monoclonal Antibody

Also Known As

V alpha 24 J alpha 18 TCR antibody (PE)

Product Synonym Names
Monoclonal V alpha 24 J alpha 18 TCR; Anti-V alpha 24 J alpha 18 TCR; V alpha 24 J alpha18; V alpha 24 J alpha 18; V alpha 24 J alpha 18 TCR; V alpha J alpha 18 TCR 24; Va24-Ja18 TCR; V alpha J alpha 18 TCR-24
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
6B11
Host
Mouse
Specificity
Mouse
Form/Format
Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.
Concentration
200 ug/ml (lot specific)
Biological Significance
The 6B11 monoclonal antibody reacts with an epitope of the CDR3 formed by the germ-line configuration of the V alpha 24 and J alpha18 of the TCR alpha locus, which results in the expression of an invariant T-cell receptor expressed by invariant NK T cells. This TCR is homologous to the murine V alpha14J alpha18. This TCR alpha chain pairs with a restricted set of rearranged TCR beta chains, with V beta11 being the most prominent in humans. NK T cells are restricted by the CD1d molecule and are activated by a CD1d-presented glycolipid ligand, which results in the rapid production of IL-4, IL-13 and IFNgamma. Although iNKT cells have NK-like cytolytic activity, they are considered regulators of immune responses because they rapidly produce large amounts of both Th1 and Th2 cytokines in autoimmune disease, infectious disease, and cancer. The number of iNKT cells present in peripheral blood of normal humans shows considerable variability ranging from 0.01-1% of total peripheral T cells.
Tag/Conjugate
PE
Preparation and Storage
Store at 2-8 degree C. Do not freeze. Protect from light.
Other Notes
Small volumes of anti-V alpha 24 J alpha 18 TCR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-V alpha 24 J alpha 18 TCR antibody
Mouse monoclonal V alpha 24 J alpha 18 TCR antibody (PE)
Applications Tested/Suitable for anti-V alpha 24 J alpha 18 TCR antibody
Flow Cytometry (FC/FACS)
This can be used at the same concentration as the experimental antibody

Flow Cytometry (FC/FACS) of anti-V alpha 24 J alpha 18 TCR antibody
Staining of normal human peripheral blood cells with CD3 antibody (FITC) and Mouse IgG1 K Isotype Control (PE) (left) or V alpha 24 J alpha 18 TCR antibody (PE) (right). Cells in the lymphocyte gate were used for analysis.
anti-V alpha 24 J alpha 18 TCR antibody Flow Cytometry (FC/FACS) (FC/FACS) image
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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