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anti-VWF antibody :: Mouse von Willebrand Factor Monoclonal Antibody

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Catalog # MBS190272
Unit / Price
  0.2 mg  /  $410 +1 FREE 8GB USB
anti-VWF antibody
Product Name

von Willebrand Factor (VWF), Monoclonal Antibody

Also Known As

Human von Willebrand Factor (vWF) Monoclonal Antibody

Product Synonym Names
von Willebrand Factor
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (6058040..6233836, complement). Location: 12p13.3
OMIM
193400
3D Structure
ModBase 3D Structure for P04275
Clonality
Monoclonal
Clone Number
VW92-3
Host
Mouse
Specificity
von Willebrand Factor [Mouse monoclonal antibody to von Willebrand Factor]
Form/Format
200 ug IgG in 10 mM PBS, pH 7.4, lyophilized.
Antigen
Human plasma von Willebrand Factor.
Activity and Specificity
This antibody specifically recognizes human von Willebrands Factor. This antibody does not inhibit the binding of vWF to the vitronectin receptor. This antibody does not react with bovine vWF.
Epitope: V8 Protease Fragment III; Ntermini Trypsin and Plasmin sensitive region
Subclass: IgG2a
Stabilizer
1% BSA
Preservatives
0.1% Sodium Azide
Dilutions Instructions
Reconstitute in distilled water to the final desired concentration.
Preparation and Storage
Lyophilized antibody is stable at 4 degree C for 2 years. Store the reconstituted solution in aliquots at -20 degree C for one year or at 4 degree C for 6 months. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-VWF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-VWF antibody
ELISA, Western Blot, Immunohistochemistry
NCBI/Uniprot data below describe general gene information for VWF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
309,265 Da[Similar Products]
NCBI Official Full Name
von Willebrand factor
NCBI Official Synonym Full Names
von Willebrand factor
NCBI Official Symbol
NCBI Official Synonym Symbols
VWD; F8VWF
  [Similar Products]
NCBI Protein Information
von Willebrand factor; OTTHUMP00000238431; coagulation factor VIII VWF
UniProt Protein Name
von Willebrand factor
UniProt Synonym Protein Names
von Willebrand antigen II
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
F8VWF  [Similar Products]
UniProt Entry Name
VWF_HUMAN
NCBI Summary for VWF
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq]
UniProt Comments for VWF
VWF: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Defects in VWF are the cause of von Willebrand disease type 1 (VWD1). A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 2 (VWD2). A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet- dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 3 (VWD3). A severe hemorrhagic disorder due to a total or near total absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous bleeding, excessive bleeding after minor trauma, and hemarthroses.

Protein type: Secreted, signal peptide; Cell adhesion; Secreted; Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; endoplasmic reticulum; extracellular region; external side of plasma membrane

Molecular Function: integrin binding; collagen binding; identical protein binding; protein binding; protein homodimerization activity; protease binding; chaperone binding; immunoglobulin binding; protein N-terminus binding; glycoprotein binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; hemostasis; response to wounding; cell adhesion; blood coagulation; liver development; blood coagulation, intrinsic pathway; cell-substrate adhesion; protein homooligomerization; placenta development

Disease: Von Willebrand Disease, Type 3; Von Willebrand Disease, Type 1; Von Willebrand Disease, Type 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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