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anti-ZAP 70 antibody :: Mouse ZAP 70 Monoclonal Antibody

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Catalog # MBS211479
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anti-ZAP 70 antibody
Product Name

ZAP 70, Monoclonal Antibody

Full Product Name

MOUSE ANTI HUMAN ZAP 70

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
176947
3D Structure
ModBase 3D Structure for P43403
Clonality
Monoclonal
Isotype
IgG1
Clone Number
SBZAP
Host
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
Approximate Protein Concentration: 0.1 mg/ml (lot specific)
Buffer Solution
Borate buffered saline
Target Species
Human
Preparation and Storage
At -20 degree C only (ship 4 degree C)
Shelf Life: 18 months from the date of despatch.
Other Notes
Small volumes of anti-ZAP 70 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ZAP 70 antibody
Mouse anti Human ZAP 70 antibody, clone SBZAP recognizes human ZAP-70, a 70kDa tyrosine protein kinase which associates with the T-cell receptor (TCR) zeta chain and undergoes phosphorylation following TCR stimulation. ZAP-70 is primarily expressed in T lymphocytes and natural killer cells, where it plays a key role in T-cell receptor (TCR) signalling. Recent studies suggest that ZAP-70 is also expressed in a population of normal immature B-cells and in B-cells from a sub-set of patients with chronic lymphocytic leukaemia.
Applications Tested/Suitable for anti-ZAP 70 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for ZAP 70. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,873 Da
NCBI Official Full Name
tyrosine-protein kinase ZAP-70 isoform 1
NCBI Official Synonym Full Names
zeta-chain (TCR) associated protein kinase 70kDa
NCBI Official Symbol
ZAP70  [Similar Products]
NCBI Official Synonym Symbols
SRK; STD; TZK; STCD; ZAP-70
  [Similar Products]
NCBI Protein Information
tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; syk-related tyrosine kinase; zeta-chain associated protein kinase, 70kD
UniProt Protein Name
Tyrosine-protein kinase ZAP-70
UniProt Synonym Protein Names
70 kDa zeta-chain associated protein; Syk-related tyrosine kinase
UniProt Gene Name
ZAP70  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
ZAP70_HUMAN
NCBI Summary for ZAP 70
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ZAP 70
ZAP70: a tyrosine kinase of the Syk family. Associates with the T-cell antigen receptor zeta-chain after TCR stimulation. Phosphorylated by Src-family kinases following antigen receptor activation. Plays a role in lymphocyte activation.

Protein type: Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; Kinase, protein; TK group; Syk family

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: T cell receptor complex; extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; immunological synapse; intercellular junction; cytosol; lipid raft

Molecular Function: protein binding; phosphotyrosine binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: cell migration; adaptive immune response; peptidyl-tyrosine phosphorylation; B cell activation; T cell activation; positive regulation of calcium-mediated signaling; negative thymic T cell selection; T cell receptor signaling pathway; protein amino acid phosphorylation; positive regulation of T cell differentiation; innate immune response; immune response; beta selection; positive regulation of alpha-beta T cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of alpha-beta T cell differentiation; T cell differentiation; positive thymic T cell selection

Disease: Selective T-cell Defect
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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