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anti-IGF1 antibody :: Mouse IGF1 Monoclonal Antibody

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Catalog # MBS530800
Unit / Price
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  0.2 mg  /  $550 +1 FREE 8GB USB
Western Blot (WB)
Product Name

IGF1, Monoclonal Antibody

Full Product Name

IGF1 antibody

Product Synonym Names
Monoclonal IGF1; Anti-IGF1; IGF1; IGF 1; IGF-1; Insulin-Like Growth Factor-1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P17647
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
Sm1.2
Host
Mouse
Species Reactivity
Avian, Chicken, Mouse, Rat
Specificity
Human
Purity/Purification
IGF1 antibody was purified by Ammonium sulfate precipitation.
Form/Format
Lyophilized from 500ul of 0.1M tris-glycine, pH 7.4.
Biological Significance
Insulin-like growth factor 1 (IGF-1) is a polypeptide protein hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 is produced primarily by the liver as an endocrine hormone and targets tissues in a paracrine/autocrine fashion.
Immunogen
IGF1 antibody was raised in mouse using human insulin-like growth factor I as the immunogen.
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-IGF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IGF1 antibody
Mouse monoclonal IGF1 antibody
Product Categories/Family for anti-IGF1 antibody
Applications Tested/Suitable for anti-IGF1 antibody
Immunohistochemistry (IHC), Immunoprecipitation (IP), Neutralization, Western Blot (WB)

Western Blot (WB) of anti-IGF1 antibody
Western blot analysis of IGF1 probed with anti-IGF1 (0.5ug/ml).
anti-IGF1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for IGF1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
17 kDa (predicted detection band MW)
NCBI Official Full Name
insulin-like growth factor I
NCBI Official Symbol
NCBI Protein Information
insulin-like growth factor I
UniProt Protein Name
Insulin-like growth factor I
UniProt Synonym Protein Names
Somatomedin
UniProt Gene Name
UniProt Synonym Gene Names
IGF-I  [Similar Products]
UniProt Entry Name
IGF1_CAVPO
UniProt Comments for IGF1
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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