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anti-DDC antibody :: Mouse Aromatic L-Amino Acid Decarboxylase, DOPA Decarboxylase, DDC Monoclonal Antibody

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Catalog # MBS609374
Unit / Price
  0.1 mL  /  $745 +1 FREE 8GB USB
anti-DDC antibody
Product Name

Aromatic L-Amino Acid Decarboxylase, DOPA Decarboxylase, DDC, Monoclonal Antibody

Full Product Name

Aromatic L-Amino Acid Decarboxylase, DOPA Decarboxylase, DDC

Product Synonym Names
Anti -Aromatic L-Amino Acid Decarboxylase, DOPA Decarboxylase, DDC
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 7; NC_000007.13 (50526134..50633154, complement). Location: 7p12.2
OMIM
107930
3D Structure
ModBase 3D Structure for P20711
Clonality
Monoclonal
Isotype
IgG
Clone Number
3H4
Host
Mouse
Species Reactivity
Bovine, Canine, Guinea Pig, Human, Monkey, Rabbit, Rat, Sheep
Specificity
Recognizes human DDC at ~50kD. Species Crossreactvity
Purity/Purification
Ascites
Ascites
Form/Format
Supplied as a liquid in 0.02% sodium azide, 40% glycerol.
Immunogen
A 16 amino acid peptide sequence near the NH2-terminus of human DDC coupled to KLH
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-DDC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DDC antibody
DDC (EC 1.1.128) belongs to the family group II Decarboxylase (DDC, GAD, HDC and TYRD). DDC catalyzes the formation of tryptamine from L-tyrosine. It also acts on 5-hydroxy-LO-tryptophan and dihydroxy-L-Phenylalanine (DOPA). Human DDC (480 aa, chromosome 7p11) is a homodimer in the native state. It requires pyridoxal phosphate as a cofactor.
Applications Tested/Suitable for anti-DDC antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-DDC antibody
Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1:1000-1:5000 (ECL) (~50kD band)
ELISA: 1:10,000-1:50,000 using 1ug/ml control peptide per well.
NCBI/Uniprot data below describe general gene information for DDC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,926 Da[Similar Products]
NCBI Official Full Name
aromatic L-amino acid decarboxylase
NCBI Official Synonym Full Names
dopa decarboxylase (aromatic L-amino acid decarboxylase)
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
aromatic-L-amino-acid decarboxylase; OTTHUMP00000159585; OTTHUMP00000209020; OTTHUMP00000209022; OTTHUMP00000209025; OTTHUMP00000209026
UniProt Protein Name
Aromatic-L-amino-acid decarboxylase
UniProt Synonym Protein Names
DOPA decarboxylase
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
DDC_HUMAN
NCBI Summary for DDC
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq]
UniProt Comments for DDC
DDC: Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Homodimer. Belongs to the group II decarboxylase family.

Protein type: Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - histidine; Amino Acid Metabolism - tryptophan; Nuclear receptor co-regulator; EC 4.1.1.28; Lyase; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: 7p12.2

Cellular Component: synaptic vesicle; cell soma; axon; cytosol

Molecular Function: protein domain specific binding; amino acid binding; aromatic-L-amino-acid decarboxylase activity; protein binding; enzyme binding; pyridoxal phosphate binding

Biological Process: circadian rhythm; amino acid metabolic process; catecholamine biosynthetic process; indolalkylamine biosynthetic process; multicellular organismal aging; isoquinoline alkaloid metabolic process; dopamine biosynthetic process; serotonin biosynthetic process; synaptic vesicle amine transport; phytoalexin metabolic process; response to pyrethroid

Disease: Aromatic L-amino Acid Decarboxylase Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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