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anti-ACE antibody :: Mouse ACE Monoclonal Antibody

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Catalog # MBS530166
Unit / Price
  0.1 mL  /  $745 +1 FREE 8GB USB
anti-ACE antibody
Product Name

ACE, Monoclonal Antibody

Also Known As

ACE antibody

Product Synonym Names
Monoclonal ACE; Anti-ACE; Angiotensin Converting Enzyme; CD143
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1306
OMIM
106180
3D Structure
ModBase 3D Structure for P12821
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2E2
Host
Mouse
Species Reactivity
Bovine, Dog, Cat, Guinea Pig, Monkey, Rabbit, Rat, Mouse
Specificity
Human
Form/Format
PBS, pH 7.4, with 150 mM NaCl.
Concentration
1.0 mg/ml (lot specific)
Biological Significance
Angiotensin I-converting enzyme an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. It is secreted by pulmonary and renal endothelial cells and catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II.
Immunogen
ACE antibody was raised in mouse using ACE (denatured) from human kidney as the immunogen.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
Other Notes
Small volumes of anti-ACE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACE antibody
Mouse monoclonal ACE antibody
Product Categories/Family for anti-ACE antibody
Applications Tested/Suitable for anti-ACE antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-ACE antibody
IHC-P: 5-10 ug/ml, WB: 5 ug/ml
NCBI/Uniprot data below describe general gene information for ACE. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
78,694 Da
NCBI Official Full Name
Angiotensin-converting enzyme
NCBI Official Synonym Full Names
angiotensin I converting enzyme
NCBI Official Symbol
NCBI Official Synonym Symbols
DCP; ICH; ACE1; DCP1; CD143; MVCD3
  [Similar Products]
NCBI Protein Information
angiotensin-converting enzyme
UniProt Protein Name
Angiotensin-converting enzyme
UniProt Synonym Protein Names
Dipeptidyl carboxypeptidase I; Kininase II; CD_antigen: CD143
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
DCP; DCP1; ACE  [Similar Products]
UniProt Entry Name
ACE_HUMAN
NCBI Summary for ACE
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
UniProt Comments for ACE
ACE: Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. Genetic variations in ACE may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in ACE are a cause of renal tubular dysgenesis (RTD). RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Genetic variations in ACE are associated with susceptibility to microvascular complications of diabetes type 3 (MVCD3). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in ACE are a cause of susceptibility to intracerebral hemorrhage (ICH). A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Belongs to the peptidase M2 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Membrane protein, integral; EC 3.4.15.1

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: extracellular space; lysosome; extracellular region; plasma membrane; integral to membrane; endosome; external side of plasma membrane

Molecular Function: peptidyl-dipeptidase activity; tripeptidyl-peptidase activity; carboxypeptidase activity; zinc ion binding; metallopeptidase activity; mitogen-activated protein kinase kinase binding; drug binding; actin binding; protein binding; endopeptidase activity; bradykinin receptor binding; exopeptidase activity; mitogen-activated protein kinase binding; chloride ion binding

Biological Process: mononuclear cell proliferation; regulation of vasodilation; angiotensin mediated regulation of renal output; neutrophil mediated immunity; regulation of angiotensin metabolic process; proteolysis; arachidonic acid secretion; angiotensin maturation; regulation of systemic arterial blood pressure by renin-angiotensin; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; regulation of smooth muscle cell migration; heart contraction; beta-amyloid metabolic process; regulation of vasoconstriction; regulation of blood pressure; peptide catabolic process; angiotensin catabolic process in blood; spermatogenesis; blood vessel remodeling; hormone catabolic process; kidney development

Disease: Microvascular Complications Of Diabetes, Susceptibility To, 3; Renal Tubular Dysgenesis; Alzheimer Disease; Hemorrhage, Intracerebral, Susceptibility To
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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