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anti-PKP2 antibody :: Mouse Plakophilin 2 Monoclonal Antibody

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Catalog # MBS531293
Unit / Price
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  5 mL  /  $310 +1 FREE 8GB USB
anti-PKP2 antibody
Product Name

Plakophilin 2 (PKP2), Monoclonal Antibody

Full Product Name

Plakophilin 2 antibody (2a + 2b)

Product Synonym Names
Monoclonal Plakophilin 2 (2a + 2b); Anti-Plakophilin 2 (2a + 2b); Anti Plakophilin 2 (2a + 2b); Plakophilin 2 (2a + 2b); Plakophilin 2a + 2b
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
602861
3D Structure
ModBase 3D Structure for Q99959
Clonality
Monoclonal
Isotype
IgG1
Clone Number
PP2/62; 86; 150
Host
Mouse
Species Reactivity
Bovine, Dog, Frog, Human, Mouse, Rat
Specificity
Human plakophilin 2
Purity/Purification
Culture supernatant
Form/Format
Supplied as a liquid with 0.09% NaN3
Biological Significance
Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Plakophilin 2 antibody (2a+2b) was raised in mouse using a synthetic carboxyterminal peptide of human plakophilin 2 as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-PKP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PKP2 antibody
Mouse monoclonal Plakophilin 2 antibody (2a + 2b)
Product Categories/Family for anti-PKP2 antibody
Applications Tested/Suitable for anti-PKP2 antibody
Immunohistochemistry (IHC) Formalin/Paraffin, Immunoprecipitation (IP), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for PKP2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
92,756 Da[Similar Products]
NCBI Official Full Name
plakophilin-2 isoform 2b
NCBI Official Synonym Full Names
plakophilin 2
NCBI Official Symbol
NCBI Official Synonym Symbols
ARVD9
  [Similar Products]
NCBI Protein Information
plakophilin-2
UniProt Protein Name
Plakophilin-2
Protein Family
UniProt Gene Name
UniProt Entry Name
PKP2_HUMAN
NCBI Summary for PKP2
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]
UniProt Comments for PKP2
plakophilin 2: May play a role in junctional plaques. Defects in PKP2 are the cause of familial arrhythmogenic right ventricular dysplasia type 9 (ARVD9); also known as arrhythmogenic right ventricular cardiomyopathy 9 (ARVC9). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 12p11

Cellular Component: nucleoplasm; desmosome; adherens junction; integral to membrane; plasma membrane; intermediate filament; intercellular junction; nucleus; cell junction

Molecular Function: protein binding; protein kinase C binding; sodium channel regulator activity; intermediate filament binding; protein complex scaffold

Biological Process: negative regulation of cell proliferation; cell-cell adhesion; gap junction assembly; heart development; lipid homeostasis; ventricular cardiac muscle morphogenesis; intermediate filament bundle assembly; maintenance of organ identity; negative regulation of cell migration

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 9
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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