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anti-CAST antibody :: Mouse Calpastatin Monoclonal Antibody

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Catalog # MBS530998
Unit / Price
  0.1 mL  /  $745 +1 FREE 8GB USB
anti-CAST antibody
Product Name

Calpastatin (CAST), Monoclonal Antibody

Popular Item
Also Known As

Calpastatin antibody

Product Synonym Names
Monoclonal Calpastatin; Anti-Calpastatin
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
204
OMIM
114090
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
2G11D6
Host
Mouse
Species Reactivity
Bovine, Dog, Human, Pig, Rabbit, Rat
Specificity
Bovine
Form/Format
PBS-diluted ascites containing 0.05% NaN3.
Concentration
1.0 mg/ml (lot specific)
Biological Significance
Calpastatin, a specific endogenous inhibitor of calpain, has a predicted molecular weight of ~77 kDa and an internal repeat of four homologous domains which allow it to inhibit multiple calpain molecules simultaneously. It functions by binding to calpain when calpain binds calcium.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Calpastatin antibody was raised in mouse using bovine skeletal muscle calpastatin as the immunogen.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-CAST antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CAST antibody
Mouse monoclonal Calpastatin antibody
Applications Tested/Suitable for anti-CAST antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin, Western Blot (WB)
Application Notes for anti-CAST antibody
ICC: 1:1,000
WB: 1:5,000
NCBI/Uniprot data below describe general gene information for CAST. It may not necessarily be applicable to this product.
NCBI GI #
NCBI Accession #
UniProt Secondary Accession #
Molecular Weight
82,437 Da[Similar Products]
NCBI Official Full Name
calpastatin, partial
UniProt Protein Name
Calpastatin
UniProt Synonym Protein Names
Calpain inhibitor; Sperm BS-17 component
Protein Family
UniProt Gene Name
UniProt Entry Name
ICAL_HUMAN
UniProt Comments for CAST
calpastatin: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. Belongs to the protease inhibitor I27 (calpastatin) family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 5q15

Cellular Component: membrane; cytoplasm; cytosol

Molecular Function: protein binding; endopeptidase inhibitor activity; cysteine protease inhibitor activity

Disease: Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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