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anti-RYR1 antibody :: Mouse RYANODINE RECEPTOR Monoclonal Antibody

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Catalog # MBS213394
Unit / Price
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  0.05 mg  /  $935 +1 FREE 8GB USB
anti-RYR1 antibody
Product Name

RYANODINE RECEPTOR (RYR1), Monoclonal Antibody

Full Product Name


Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Clone Number
RYR.1 (G-1)
Species Reactivity
Bovine, Dog, Mouse, Pig, Rat
Purified IgG - liquid
IgG concentration 0.5 mg/ml (lot specific)
Perservative Stabilisers
0.01% Sodium azide
Buffer Solution
Phosphate buffered saline
Target Species
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-RYR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RYR1 antibody
Mouse anti Human Ryanodine Receptor antibody, clone RYR-1 recognizes the human ryanodine receptor 1, also known as Skeletal muscle calcium release channel or skeletal muscle ryanodine receptor. Ryanodine receptor 1 is a is a large 5038 amino acid ~500kDa multi pass sarcoplamic reticulum associated transmembrane protein containing three B30.2/SPRY domains and five MIR domains. Mouse anti Human Ryanodine Receptor antibody, clone RYR-1 recognizes an epitope within the C-terminal cytoplasmic domain of the ryanodine receptor (UniProt: P21817). Ryanodine receptors have been shown to play critical roles in the intracellular Ca2+ signaling occurring during cell activation in muscle cells and non-muscle cells. Mouse anti Human Ryanodine Receptor antibody, clone RYR-1 reacts with ryanodine receptor isolated from a variety of cell types (e.g. lymphocytes, macrophages, granulocytes, fibroblasts, epithelial, endothelial cells, skeletal muscle, cardiac muscle and brain tissues). Defects in the ryanodine receptor 1 gene are associated with malignant hyperthermia (Gillard et al. 1992), central core disease of muscle (Quane et al. 1993) and certain congential myopathies (Monnier et al. 2000).
Applications Tested/Suitable for anti-RYR1 antibody
Immunohistology Frozen, ELISA (EIA), Flow cytometry (FC/FACS), Immunoblotting (IB), Immunofluorescence (IF)*
Application Notes for anti-RYR1 antibody
Immunohistology - Frozen: Maximum Dilution: 1/100;
ELISA: Maximum Dilution: 1/1000;
Flow Cytometry: Maximum Dilution: 1/500;
Immunoblotting: Maximum Dilution: 1/100;
Immunofluorescence: Maximum Dilution: 1/100; Application Note: Use indirect immunofluorescence. Visualization by confocal microscopy is required, as detection by standard fluorescent microscopy will not be adequate to detect the RyR. Additionally, fluorescent, not enzymatic, detection is required. Due to the intensity of confocal lasers, use of an anti-fading agent, such as DABCO, is strongly recommended.
NCBI/Uniprot data below describe general gene information for RYR1. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
564,550 Da[Similar Products]
NCBI Official Full Name
ryanodine receptor
NCBI Official Synonym Full Names
ryanodine receptor 1 (skeletal)
NCBI Official Symbol
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
ryanodine receptor 1; central core disease of muscle; protein phosphatase 1, regulatory subunit 137; sarcoplasmic reticulum calcium release channel; skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; type 1-like ryanodine receptor
UniProt Protein Name
Ryanodine receptor 1
UniProt Synonym Protein Names
Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
RYDR; RYR-1; RyR1  [Similar Products]
UniProt Entry Name
NCBI Summary for RYR1
This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for RYR1
RYR1: Calcium channel that controls communication between transverse-tubules and sarcoplasmic reticulum. Contraction of skeletal muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Can mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal development of muscle fibers, skeletal muscle, heart morphogenesis, and skin development and ossification during embryogenesis. Defects in RYR1 are the cause of malignant hyperthermia susceptibility type 1 (MHS1) and central core disease of muscle (CCD). CCD is an autosomal dominant congenital myopathy, but a severe autosomal recessive form also exists. Defects in RYR1 are the cause of multiminicore disease with external ophthalmoplegia (MMDO), congenital myopathy with fiber-type disproportion (CFTD). Defects in RYR1 may be a cause of Samaritan myopathy, a congenital myopathy with benign course. Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Channel, calcium; Transporter, ion channel; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: I band; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; sarcoplasmic reticulum; integral to plasma membrane; cytoplasm; T-tubule; junctional membrane complex; plasma membrane; cell cortex

Molecular Function: voltage-gated calcium channel activity; calmodulin binding; protein binding; protease binding; calcium-release channel activity; calcium channel activity; ryanodine-sensitive calcium-release channel activity

Biological Process: skin development; cytosolic calcium ion homeostasis; muscle contraction; calcium ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; skeletal muscle fiber development; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; transmembrane transport; response to caffeine

Disease: Minicore Myopathy With External Ophthalmoplegia; Malignant Hyperthermia, Susceptibility To, 1; Central Core Disease Of Muscle; Myopathy, Congenital, With Fiber-type Disproportion
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