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anti-INS antibody :: Mouse Insulin+Proinsulin Monoclonal Antibody

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Catalog # MBS531145
Unit / Price
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  1 mg  /  $810 +1 FREE 8GB USB
anti-INS antibody
Product Name

Insulin+Proinsulin, Monoclonal Antibody

Popular Item
Full Product Name

Insulin+Proinsulin antibody (biotin)

Product Synonym Names
Monoclonal Insulin+Proinsulin; Anti-Insulin+Proinsulin; Insulin/Proinsulin; Insulin+Proinsulin; Insulin & Proinsulin; Anti Insulin+Proinsulin
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
125852
3D Structure
ModBase 3D Structure for P01308
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
D3E7
Host
Mouse
Species Reactivity
Reacts with human, bovine, and porcine insulin and proinsulin
Specificity
Rat, Mouse
Purity/Purification
Insulin+Proinsulin antibody (biotin) was purified by chromatography on protein A Sepharose.
Form/Format
Liquid in 20mM Tris-HCl, pH 7.5, 150mM Sodium Chloride, containing 0.09 Sodium Azide. Antibody conjugated to Biotinisothiocyanate.
Concentration
1.3 mg/ml (lot specific)
Biological Significance
Insulin is a hormone that is central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, muscle, and fat tissue to take up glucose from the blood, storing it as glycogen in the liver and muscle. Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. In humans, proinsulin is encoded by the INS gene.
Immunogen
Insulin & ProInsulin
Tag/Conjugate
Biotin
Affinity Constant
6.3 x 10-8M
Biohazard Information
This product is sold as an antibody preparation for research use only. Standard Laboratory Practices should be followed when handling this material. This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Preparation and Storage
Store at 4°C.
Other Notes
Small volumes of anti-INS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-INS antibody
Mouse monoclonal Insulin+Proinsulin antibody (biotin)
Applications Tested/Suitable for anti-INS antibody
Suitable for Immunohistochemistry on frozen sections.
Application Notes for anti-INS antibody
Optimal conditions to be determined by end user.
NCBI/Uniprot data below describe general gene information for INS. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,537 Da[Similar Products]
NCBI Official Full Name
insulin preproprotein
NCBI Official Synonym Full Names
insulin
NCBI Official Symbol
NCBI Official Synonym Symbols
IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
  [Similar Products]
NCBI Protein Information
insulin
UniProt Protein Name
Insulin
Protein Family
UniProt Gene Name
UniProt Entry Name
INS_HUMAN
NCBI Summary for INS
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
UniProt Comments for INS
Insulin: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds. Belongs to the insulin family.

Protein type: Hormone; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular space; Golgi lumen; endoplasmic reticulum lumen; extracellular region

Molecular Function: insulin-like growth factor receptor binding; identical protein binding; protein binding; protease binding; hormone activity; insulin receptor binding

Biological Process: positive regulation of nitric oxide biosynthetic process; glucose homeostasis; positive regulation of vasodilation; activation of NF-kappaB transcription factor; negative regulation of protein oligomerization; positive regulation of glucose import; regulation of protein localization; cell-cell signaling; negative regulation of gluconeogenesis; acute-phase response; regulation of transmembrane transporter activity; negative regulation of NAD(P)H oxidase activity; positive regulation of mitosis; positive regulation of nitric-oxide synthase activity; activation of protein kinase B; negative regulation of acute inflammatory response; glucose metabolic process; positive regulation of lipid biosynthetic process; positive regulation of protein amino acid autophosphorylation; positive regulation of cell growth; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein catabolic process; positive regulation of cell differentiation; regulation of amino acid metabolic process; negative regulation of glycogen catabolic process; wound healing; positive regulation of glycogen biosynthetic process; positive regulation of cellular protein metabolic process; glucose transport; regulation of protein secretion; positive regulation of MAPKKK cascade; regulation of transcription, DNA-dependent; negative regulation of lipid catabolic process; negative regulation of vasodilation; positive regulation of cell proliferation; negative regulation of proteolysis; negative regulation of protein secretion; MAPKKK cascade; negative regulation of fatty acid metabolic process; alpha-beta T cell activation; endocrine pancreas development; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; cellular protein metabolic process; fatty acid homeostasis; positive regulation of glycolysis; insulin receptor signaling pathway; energy reserve metabolic process; positive regulation of insulin receptor signaling pathway; regulation of insulin secretion; positive regulation of DNA replication; positive regulation of cytokine secretion; positive regulation of cell migration

Disease: Diabetes Mellitus, Insulin-dependent, 2; Diabetes Mellitus, Permanent Neonatal; Hyperproinsulinemia; Maturity-onset Diabetes Of The Young, Type 10
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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