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anti-SAG antibody :: Mouse S-Arrestin Monoclonal Antibody

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Catalog # MBS605379
Unit / Price
  0.1 mL  /  $530 +1 FREE 8GB USB
anti-SAG antibody
Product Name

S-Arrestin (SAG), Monoclonal Antibody

Also Known As

S-Arrestin (S Arrestin, S-arrestin, 48kD Protein, DKFZp686I1383, Rod Photoreceptor Arrestin, S Antigen, S-antigen Retina and Pineal Gland, S AG, SAG, S-AG)

Product Synonym Names
Anti -S-Arrestin (S Arrestin, S-arrestin, 48kD Protein, DKFZp686I1383, Rod Photoreceptor Arrestin, S Antigen, S-antigen Retina and Pineal Gland, S AG, SAG, S-AG)
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (234216309..234255701). Location: 2q37.1
OMIM
181031
3D Structure
ModBase 3D Structure for P10523
Clonality
Monoclonal
Isotype
IgG1
Clone Number
9G8
Host
Mouse
Species Reactivity
Bovine, Human, Porcine
Specificity
This antibody is specific for arrestin protein. Species Crossreactivity: This antibody reacts with human, bovine, porcine, and rat (weakly).
Purity/Purification
Purified
Purified
Form/Format
Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.
Immunogen
Porcine retinal S-antigen (arrestin). [Swiss-Prot# P79260].
Positive Control
Retina lysate
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 3 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-SAG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SAG antibody
S-antigen, also identified as arrestin, is a protein involved in the regulation of phototransduction.
Product Categories/Family for anti-SAG antibody
Applications Tested/Suitable for anti-SAG antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-SAG antibody
Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry (Fr).
NCBI/Uniprot data below describe general gene information for SAG. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,120 Da[Similar Products]
NCBI Official Full Name
S-arrestin
NCBI Official Synonym Full Names
S-antigen; retina and pineal gland (arrestin)
NCBI Official Symbol
NCBI Official Synonym Symbols
RP47; S-AG; DKFZp686D1084; DKFZp686I1383
  [Similar Products]
NCBI Protein Information
S-arrestin; arrestin 1; 48 kDa protein; OTTHUMP00000203381; rod photoreceptor arrestin; retinal S-antigen (48 KDa protein)
UniProt Protein Name
S-arrestin
UniProt Synonym Protein Names
48 kDa protein; Retinal S-antigen; S-AG; Rod photoreceptor arrestin
Protein Family
UniProt Gene Name
UniProt Entry Name
ARRS_HUMAN
NCBI Summary for SAG
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq]
UniProt Comments for SAG
SAG: Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated- phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Retina and pineal gland. Belongs to the arrestin family.

Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: photoreceptor inner segment; photoreceptor outer segment; cytosol

Molecular Function: opsin binding; phosphoprotein binding; protein phosphatase inhibitor activity

Biological Process: rhodopsin mediated signaling; phototransduction, visible light; cell surface receptor linked signal transduction; regulation of rhodopsin mediated signaling; visual perception; negative regulation of catalytic activity

Disease: Oguchi Disease 1; Retinitis Pigmentosa 47
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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