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anti-GSN antibody :: Mouse GSN / Gelsolin Monoclonal Antibody

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Catalog # MBS249458
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

GSN / Gelsolin, Monoclonal Antibody

Popular Item
Also Known As

Anti-GSN / Gelsolin Antibody (clone GEL-42) IHC-plus

Product Synonym Names
Mouse Monoclonal [clone GEL-42] (IgG1) to Human GSN / Gelsolin; Human GSN / Gelsolin; ADF; AGEL; Brevin; Actin-depolymerizing factor; Gelsolin precursor; plasma; Gelsolin
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
782
OMIM
105120
3D Structure
ModBase 3D Structure for P06396
Clonality
Monoclonal
Isotype
IgG1
Clone Number
GEL-42
Host
Mouse
Species Reactivity
Rabbit, Bovine, Human
Specificity
Human, rabbit, bovine. No cross reactivity with other proteins.
Purity/Purification
Affinity purified
Form/Format
1.2% sodium acetate, 2 mg BSA, 0.01 mg sodium azide as preservative
Concentration
1 mg/ml (lot specific)
Immunogen
GSN / Gelsolin antibody was raised against human plasma gelsolin.
Immunogen Description
Human plasma gelsolin.
Immunogen Type
Purified protein
Resuspension Liquid Description
1.2% sodium acetate or neutral PBS.
Target Species
Human
Preparation and Storage
Short term: 4 degree C
Long term: -20 degree C
Other Notes
Small volumes of anti-GSN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GSN antibody
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Applications Tested/Suitable for anti-GSN antibody
Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)
Application Notes for anti-GSN antibody
IHC-Fr (1 - 2 ug/ml)
IHC-P (1 - 10 ug/ml)
WB (0.5 - 1 ug/ml)

Immunohistochemistry (IHC) of anti-GSN antibody
Anti-GSN / Gelsolin antibody IHC staining of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GSN antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for GSN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,485 Da
NCBI Official Full Name
gelsolin isoform a
NCBI Official Synonym Full Names
gelsolin
NCBI Official Symbol
NCBI Official Synonym Symbols
ADF; AGEL
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NCBI Protein Information
gelsolin
UniProt Protein Name
Gelsolin
UniProt Synonym Protein Names
AGEL; Actin-depolymerizing factor; ADF; Brevin
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
GELS_HUMAN
NCBI Summary for GSN
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GSN
Gelsolin: a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Its expression is significantly decreased in many tumors and transformed cell lines. Gelsolin and other proteins including E-cadherin, BRCA, p21WAF, HoxA5, and retinoic acid receptor II are regulated by epigenetic changes in breast cancers. Gelsolin helps mediate the ability of HDAC inhibitors to protect neurons from oxygen/glucose deprivation. Two human isoforms are produced by alternative initiation.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Actin-binding; Nuclear receptor co-regulator; Secreted

Chromosomal Location of Human Ortholog: 9q33

Cellular Component: actin cap; actin cytoskeleton; cortical actin cytoskeleton; cytoplasm; cytosol; extracellular region; extracellular space; focal adhesion; lamellipodium; myelin sheath; nucleus; perinuclear region of cytoplasm; plasma membrane; podosome; ruffle; sarcoplasm

Molecular Function: actin binding; calcium ion binding; myosin II binding; protein binding; protein domain specific binding

Biological Process: actin filament capping; actin filament polymerization; actin filament severing; actin nucleation; aging; apoptosis; barbed-end actin filament capping; cell structure disassembly during apoptosis; cellular protein metabolic process; extracellular matrix disassembly; negative regulation of virion penetration into host cell; oligodendrocyte development; phagocytosis, engulfment; phosphoinositide-mediated signaling; positive regulation of actin nucleation; programmed cell death; protein destabilization; response to ethanol; response to folic acid; sequestering of actin monomers; striated muscle atrophy; tissue regeneration

Disease: Amyloidosis, Finnish Type
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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