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anti-DLG4 antibody :: Mouse Postsynaptic Density Protein 95 Monoclonal Antibody

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Catalog # MBS600612
Unit / Price
  0.1 mg  /  $690 +1 FREE 8GB USB
anti-DLG4 antibody
Product Name

Postsynaptic Density Protein 95 (DLG4), Monoclonal Antibody

Full Product Name

Postsynaptic Density Protein 95 (PSD-95, PSD95, Discs Large Homolog 4, DLG4, Post-synaptic Density Protein 95, Synapse-associated Protein 90, SAP90, SAP-90)

Product Synonym Names
Anti -Postsynaptic Density Protein 95 (PSD-95, PSD95, Discs Large Homolog 4, DLG4, Post-synaptic Density Protein 95, Synapse-associated Protein 90, SAP90, SAP-90)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (7093209..7123369, complement). Location: 17p13.1
OMIM
602887
3D Structure
ModBase 3D Structure for P78352
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
2Q128
Host
Mouse
Species Reactivity
Bovine, Mouse, Rat
Specificity
Reacts with recombinant rat PSD-95 and identifies a band at approximately 95kD, corresponding to PSD-95, on immunoblots of rat brain, mouse brain and bovine brain extracts. Also present in rat brain and mouse brain tissue extracts are bands of approximately 80kD and 50kD. PSD-95 is believed to initiate NMDA receptor clustering on the post synaptic membrane.
Purity/Purification
Purified
Purified immunoglobulin
Form/Format
Liquid in PBS. Contains no preservative.
Immunogen
Recombinant rat PSD-95
Preparation and Storage
-20 degree C
Other Notes
Small volumes of anti-DLG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-DLG4 antibody
Applications Tested/Suitable for anti-DLG4 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-DLG4 antibody
Western Blot: 1:1000 (ECL) Immunofluorescence
NCBI/Uniprot data below describe general gene information for DLG4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,495 Da[Similar Products]
NCBI Official Full Name
post-synaptic density protein 95
NCBI Official Synonym Full Names
discs, large homolog 4 (Drosophila)
NCBI Official Symbol
NCBI Official Synonym Symbols
PSD95; SAP90; SAP-90
  [Similar Products]
NCBI Protein Information
disks large homolog 4; discs large homolog 4; Tax interaction protein 15; synapse-associated protein 90; postsynaptic density protein 95; post-synaptic density protein 95
UniProt Protein Name
Disks large homolog 4
UniProt Synonym Protein Names
Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
PSD95; PSD-95; SAP-90; SAP90  [Similar Products]
UniProt Entry Name
DLG4_HUMAN
NCBI Summary for DLG4
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DLG4
PSD-95: a membrane associated guanylate kinase (MAGUK) scaffolding protein located in neural postsynaptic densities. Associates with NMDA receptor NR2 subunits via glutamate serine (aspartate/glutamate) valine motifs in the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Its overexpression or depletion changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. Binds tissue-type plasminogen activator (tPA), mediating neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. Interacts through its first two PDZ domains with NMDAR2A, NMDAR2B, NMDAR2C, NMDAR2D, ACCN3, certain splice forms of NMDAR1, KV4.2, CXADR and synGAP. Interacts through its first two PDZ domains with Kv1.1, Kv1.2, Kv1.3, Kv1.4 and HER4. Interacts through its first PDZ domain with GluR6 and Kv1.4. Interacts through its second PDZ domain with the PDZ domain of nNOS or the C-terminus of NOS1AP. May interact with 5-HT(2A). Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with SAPAP1, SAPAP2, SAPAP3, SAPAP4, MAP1A, and BEGAIN. Interacts through its guanylate kinase-like domain with KIF13B. Two alternatively spliced human isoforms have been reported. Palmitoylation of isoform 1 is required for targeting to postsynaptic density.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cortical cytoskeleton; dendrite cytoplasm; voltage-gated potassium channel complex; basolateral plasma membrane; endoplasmic reticulum; postsynaptic density; dendritic spine; excitatory synapse; postsynaptic membrane; synaptic vesicle; extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; ionotropic glutamate receptor complex; synapse; cell junction

Molecular Function: P2Y1 nucleotide receptor binding; protein C-terminus binding; guanylate kinase activity; ionotropic glutamate receptor binding; protein binding; beta-1 adrenergic receptor binding; protein complex binding; acetylcholine receptor binding; D1 dopamine receptor binding; protein phosphatase binding; PDZ domain binding

Biological Process: regulation of long-term neuronal synaptic plasticity; axon guidance; nervous system development; synaptic vesicle maturation; social behavior; learning; signal transduction; positive regulation of synaptic transmission; establishment and/or maintenance of epithelial cell polarity; synaptic transmission; elevation of cytosolic calcium ion concentration; establishment of protein localization; protein complex assembly; neuromuscular process controlling balance; negative regulation of receptor internalization; nucleotide phosphorylation
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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