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anti-CNN1 antibody :: Mouse Calponin Monoclonal Antibody

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Catalog # MBS370013
Unit / Price
  5 Control Slides  /  $130 +1 FREE 8GB USB
  0.1 mL (Concentrate)  /  $180 +1 FREE 8GB USB
  3 ml (Prediluted)  /  $195 +1 FREE 8GB USB
  7 mL (Prediluted)  /  $255 +1 FREE 8GB USB
  0.5 mL (Concentrate)  /  $335 +1 FREE 8GB USB
  15 mL (Prediluted)  /  $410 +1 FREE 8GB USB
  1 mL (Concentrate)  /  $445 +1 FREE 8GB USB
Product Name

Calponin (CNN1), Monoclonal Antibody

Full Product Name

Calponin

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.9 (11649579..11661138). Location: 19p13.2-p13.1
OMIM
600806
3D Structure
ModBase 3D Structure for P51911
Clonality
Monoclonal
Isotype
IgG1/K
Clone Number
CALP-A6
Host
Mouse
Species Reactivity
Human, Canine, Feline
Form/Format
Anti-Calponin (CALP-A6) is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Control
Appendix, Uterus, Leiomyoma
Localization
Cytoplasmic
Reactivity Note
Paraffin, Frozen
Preparation and Storage
Store at 2 to 8 degree C in the dark.
ISO Certification
Manufactured in an ISO 13485:2016 Certified Laboratory.
Other Notes
Small volumes of anti-CNN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CNN1 antibody
Calponin is a 34 kDa polypeptide that interacts with actin, tropomyosin, and calmodulin. It is involved in smooth-muscle contraction mechanisms and is restricted exclusively to smooth-muscle tissue. Calponin is a calcium-binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein kinase (which is dependent upon calcium binding to calmodulin) releases the calponin's inhibition of the smooth-muscle ATPase. Calponin has been found to be useful in differentiating benign sclerosing lesions of the breast from Carcinoma. Calponin positivity has also been noted in Malignant Myoepithelioma and Pleomorphic Adenoma of Salivary Gland origin, as well as in Angiomatoid Malignant Fibrous Histiocytoma.

Dilution Information of anti-CNN1 antibody
anti-CNN1 antibody Dilution Information image
Immunohistochemistry (IHC) of anti-CNN1 antibody
anti-CNN1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CNN1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,170 Da[Similar Products]
NCBI Official Full Name
calponin
NCBI Official Synonym Full Names
calponin 1, basic, smooth muscle
NCBI Official Symbol
NCBI Official Synonym Symbols
SMCC; Sm-Calp
  [Similar Products]
NCBI Protein Information
calponin-1; basic calponin; calponins, basic; calponin H1, smooth muscle
UniProt Protein Name
Calponin-1
UniProt Synonym Protein Names
Basic calponin; Calponin H1, smooth muscle
Protein Family
UniProt Gene Name
UniProt Entry Name
CNN1_HUMAN
UniProt Comments for CNN1
Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity

Subunit structure: Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1

Tissue specificity: Smooth muscle, and tissues containing significant amounts of smooth muscle.

Sequence similarities: Belongs to the calponin family.Contains 3 calponin-like repeats.Contains 1 CH (calponin-homology) domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-CNN1 antibody
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